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JoVE Journal
Biology

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Analyzing Large Protein Complexes by Structural Mass Spectrometry
 

Analyzing Large Protein Complexes by Structural Mass Spectrometry

Article DOI: 10.3791/1954
June 19th, 2010

Chapters

Summary June 19th, 2010

Mass spectrometry has proven to be a valuable tool for analyzing large protein complexes. This method enables insights into the composition, stoichiometry and overall architecture of multi-subunit assemblies. Here, we describe, step-by-step, how to perform a structural mass spectrometry analysis, and characterize macromolecular structures.

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