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Journal / Immunology and Infection / Generation of Multivirus-specific T Cells to…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Article DOI: 10.3791/2736-v • 08:52 min • May 27th, 2011
May 27th, 2011 •
1, 1, 1, 1
1Center for Cell and Gene Therapy, Baylor College of Medicine

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Summary
Automatic Translation

A rapid, simple and cost-effective protocol for the generation of donor-derived multivirus-specific CTLs (rCTL) for infusion to allogeneic hematopoietic stem cell transplant (HSCT) recipients at risk of developing CMV, Adv or EBV infections. This manufacturing process is GMP-compliant and should ensure the broader implementation of T-cell immunotherapy beyond specialized centers.

Tags

Multivirus-specific T Cells Viral Infections Allogeneic Hematopoietic Stem Cell Transplant Epstein Barr Virus Cytomegalovirus Adenovirus Antigen Presenting Cells Cytotoxic T Lymphocytes GMP-compliant CTL Production Protocol Dendritic Cells DNA Plasmids IL-4 IL-7
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