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Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics
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Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics

Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics

DOI:
10.3791/50019-v

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08:43 min

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November 30, 2012

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, , ,
1Department of Neurological Surgery,Vanderbilt University School of Medicine

Chapters

  • 00:05Title
  • 01:40Intubate the Rat
  • 03:21Establish IV Anesthesia
  • 04:17Expose the Bifurcation of the Common Carotid Artery and Catherize the External Carotid Artery
  • 07:38Representative Blood-brain Barrier Disruption
  • 08:12Conclusion

Summary

Automatic Translation

Automatic Translation

Blood-brain barrier disruption aids the delivery of certain drugs to the brain. Mannitol delivered intra-arterially shrinks cells surrounding blood vessels in order to physically disrupt the barrier.

Tags

Keywords: Blood-brain BarrierNeurovascular TherapeuticsEndothelial CellsTight JunctionsBlood-brain Barrier DisruptionOsmotic DisruptionMannitolPharmacological DisruptionFocused UltrasoundMicrobubblesIntracerebral InfusionTranslational Research

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