Journal
/
Chemistry
/
Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
JoVE Journal
Chemistry
This content is Free Access.
JoVE Journal Chemistry
Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

DOI:
10.3791/50890-v

•

15:33 min

•

October 29, 2013

•

, ,
1Department of Biomedical Engineering,University of Rochester, 2Department of Chemical Engineering,University of Rochester, 3Center for Musculoskeletal Research,University of Rochester Medical Center

Chapters

  • 00:05Title
  • 01:58Microwave-assisted Synthesis of PEGDM and Characterization of Functionalization
  • 05:07Microwave-assisted Functionalization of On-resin Peptides
  • 08:23Characterization of Peptide Functionalization
  • 09:35Characterization of Functionalized PEGDM and Peptides, and Demonstration of Their Use in Hydrogel Formation
  • 14:39Conclusion

Summary

Automatic Translation

Automatic Translation

This video will illustrate a rapid, efficient method to methacrylate poly(ethylene glycol), enabling chain polymerizations and hydrogel synthesis. It will demonstrate how to similarly introduce methacrylamide functionalities into peptides, detail common analytical methods to assess functionalization efficiency, provide suggestions for troubleshooting and advanced modifications, and demonstrate typical hydrogel characterization techniques.

Tags

Keywords: Poly(ethylene Glycol)PEGPEGDMMicrowave-assisted FunctionalizationMethacrylationOn-resin Peptide FunctionalizationMethacrylamideHydrogel FormationDrug DeliveryRegenerative MedicineAnalytical MethodsNMRMALDI-ToFHydrogel PropertiesMesh SizeStiffnessDrug Release

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

check_url/50890?article_type=v

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
check_url/50890?article_type=v

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
check_url/50890?article_type=v

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis
check_url/50890?article_type=v

Ethylene Polymerizations Using Parallel Pressure Reactors and a Kinetic Analysis of Chain Transfer Polymerization
check_url/50890?article_type=v

Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles
check_url/50890?article_type=v

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates
check_url/50890?article_type=v

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
check_url/50890?article_type=v

Reducing Willow Wood Fuel Emission by Low Temperature Microwave Assisted Hydrothermal Carbonization
check_url/50890?article_type=v

Calcium Carbonate Formation in the Presence of Biopolymeric Additives
check_url/50890?article_type=v

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Read Article