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Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

DOI:
10.3791/54502-v

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12:07 min

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April 16, 2018

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, , , , ,
1Department of Chemical Engineering,McMaster University

Chapters

  • 00:04Title
  • 00:49Fabrication of Hydrazone-crosslinked Bulk Poly(Oligoethylene Glycol Methacrylate)(POEGMA) or Poly(N-Isopropylacrylamide) (PNIPAM) Hydrogels
  • 02:41Fabrication of Hydrazone-crosslinked PNIPAM Gel Microparticles via Reactive Microfluidics
  • 06:18Thermally-driven Reactive Self-assembly of Hydrazone-crosslinked PNIPAM Nanogels
  • 07:34Fabrication of Hydrazone- crosslinked POEGMA Nanofibers via Reactive Electrospinning
  • 09:28Results: Bulk, Microscale, and Nanoscale Thermoresponsive Hydrogels
  • 11:17Conclusion

Summary

Automatic Translation

Automatic Translation

Protocols are described for the fabrication of degradable thermoresponsive hydrogels based on hydrazone cross-linking of polymeric oligomers on the bulk scale, microscale, and nanoscale, the latter for preparation of both gel nanoparticles and nanofibers.

Tags

Keywords: Degradable Thermoresponsive HydrogelsReactive ExtrusionMicrofluidicsSelf-assemblyElectrospinningHydrazone ChemistryMicrogelsNanogelsNanofibersFolic GelsPoly(NIPAM)HydrazideAldehydeDrug DeliveryNanotherapeutics

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