Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Biology / In Vitro Aggregation Assays Using…
JoVE Journal
Biology

A subscription to JoVE is required to view this content.
You will only be able to see the first 2 minutes.

JoVE Journal Biology
In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Generation of Stable Human Cell Lines with Tetracycline-inducible (Tet-on) shRNA or cDNA Expression
Journal (Biology)
Generation of Stable Human Cell Lines with Tetracycline-inducible (Tet-on) shRNA or cDNA Expression
Genetic Modification of Cyanobacteria by Conjugation Using the CyanoGate Modular Cloning Toolkit
Journal (Biology)
Genetic Modification of Cyanobacteria by Conjugation Using the CyanoGate Modular Cloning Toolkit
 

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Article DOI: 10.3791/51537 • 09:22 min
January 2nd, 2015 •
*1, *1, 1
1Department of Biochemistry and Molecular Biology, Michigan State University
* These authors contributed equally

Chapters

Summary
Automatic Translation
January 2nd, 2015

Unmodified and hyperphosphorylated tau proteins were used in two in vitro aggregation assays to reveal the hyperphosphorylation-dependent fast aggregation kinetics. These assays pave the way for future screens for compounds that can modulate the propensity of hyperphosphorylated tau to form fibrils that underlie the progression of Alzheimer’s disease.

Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter