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Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun
Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun
JoVE Journal
Neuroscience
This content is Free Access.
JoVE Journal Neuroscience
Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun

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06:40 min

October 24, 2014

DOI:

06:40 min
October 24, 2014

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Summary

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Recent improvements in organotypic brain slice preparations have permitted their exploitation for biotechnological applications. Organotypic slices maintain local structural characteristics of in vivo biology, including functional synaptic connections. Here we present a regioselective biolistic delivery method to label and genetically manipulate these slices.

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