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Journal / Neuroscience / Dorsal Root Ganglia Neurons and Differentiated…
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Neuroscience

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JoVE Journal Neuroscience
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Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration

Article DOI: 10.3791/52543 • 09:17 min • February 26th, 2015
February 26th, 2015 •
1, 2, 2,3
1Centre for Neuroprosthesis, EPFL | STI | IMT/IBI | LSBI, 2Blond McIndoe Research Laboratories, Institute of Inflammation & Repair, The University of Manchester, 3University Hospital of South Manchester

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Summary
Automatic Translation

Dorsal root ganglia (DRG) are structures containing the sensory neurons of the peripheral nervous system. When dissociated, they can be co-cultured with SC-like adipose-derived stem cells (ASC), providing a valuable model to study in vitro nerve regeneration and myelination, mimicking the in vivo environment at the injury site.

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Dorsal Root Ganglia Neurons Differentiated Adipose-derived Stem Cells In Vitro Co-culture Model Peripheral Nerve Regeneration Myelination Schwann Cells Interactions Membrane Receptors Growth Factors Proteins Culture Medium Neurite Sprouting ASC (adipose-derived Stem Cells) Tissue Engineering Applications Co-culture Model Adult Rats
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