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Genetics

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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
 

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Article doi: 10.3791/54967
April 26th, 2017

Summary April 26th, 2017

This report describes a bioengineering method to design and construct novel Artificial Splicing Factors (ASFs) that specifically modulate the splicing of target genes in mammalian cells. This method can be further expanded to engineer various artificial factors to manipulate other aspects of RNA metabolism.

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