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JoVE Journal

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Variations on Negative Stain Electron Microscopy Methods

Variations on Negative Stain Electron Microscopy Methods: Tools for Tackling Challenging Systems

Article DOI: 10.3791/57199
February 6th, 2018


Summary February 6th, 2018

Negative stain EM is a powerful technique for visualizing macromolecular structure, but different staining techniques can produce varying results in a sample dependent manner. Here several negative staining approaches are described in detail to provide an initial workflow for tackling the visualization of challenging systems.


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