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JoVE Journal Neuroscience
Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
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Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Article DOI: 10.3791/59189-v • 09:54 min • May 10th, 2019
May 10th, 2019 •
*1, *1, 1, 1, 1, 1, 1, 2, 1, 1
1Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, 2Department of Otology, Shengjing Hospital of China Medical University
* These authors contributed equally

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Summary
Automatic Translation

This manuscript describes an experimental protocol for evaluating the morphological characteristics and functional status of ribbon synapses in normal mice. The present model is also suitable for noise-induced and age-related cochlear synaptopathy-restricted models. The correlative results of previous mouse studies are also discussed.

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Morphological Evaluation Functional Evaluation Ribbon Synapses Specific Frequency Regions Cochlea Basilar Membrane Synapse Numbers Function Analysis Cochlear Localization Place Frequency Maps Cochleogram Data Microscope Cochlear Neuropathy Hearing Loss Tinnitus Hyperacusis Toe Pinch Response Anesthetized Mouse Recording Electrode Reference Electrode Ground Electrode Closed Field Speaker Auditory Brainstem Response (ABR) Sound Pressure Levels
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