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Taking the Next Step: a Neural Coaptation Orthotopic Hind Limb Transplant Model to Maximize Functional Recovery in Rat

Article DOI: 10.3791/60777-v • 14:18 min • August 30th, 2020
August 30th, 2020 •
1,3, 1,2, 1, 1, 1, 1, 1,4, 1, 1, 1, 1
1Comprehensive Transplant Center and Department of Surgery, Feinberg School of Medicine, Northwestern University, 2Department of Surgery, University of Illinois at Chicago, 3Department of Surgery, Tianjin Occupational Diseases Precaution and Therapeutic Hospital, 4Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University

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This protocol presents a robust, reproducible model of vascularized composite allotransplant (VCA) geared toward simultaneous study of immunology and functional recovery. The time invested in meticulous technique in a right mid-thigh hind limb orthotopic transplant with hand sewn vascular anastomoses and neural coaptation yields the ability to study functional recovery.

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Neural Coaptation Orthotopic Hind Limb Transplant Functional Recovery Rat Orthotopic Right Hind Limb Transplant Model Mid-thigh Transplanted Rat Donor Rat Recipient Rat Bone Attachment Artery Attachment Vein Attachment Nerve Attachment Muscle Attachment Skin Attachment Vascularized Composite Allotransplant (VCA) Microsurgical Techniques Hand-sewn Vascular Anastomosis Neural Coaptation Learning Curve Microsurgeon Animal Care And Use Committee
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