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JoVE Journal
Biochemistry

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Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
 

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Article DOI: 10.3791/62950-v
August 27th, 2021

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Summary August 27th, 2021

Ubiquitination is a critical protein post-translational modification, dysregulation of which has been implicated in numerous human diseases. This protocol details how phage display can be utilized to isolate novel ubiquitin variants that can bind and modulate the activity of E3 ligases that control the specificity, efficiency, and patterns of ubiquitination.

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