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JoVE Journal
Chemistry

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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
 

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Article DOI: 10.3791/64289-v
September 28th, 2022

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Summary September 28th, 2022

This protocol presents the synthesis of cyclic peptides via bisalkylation between cysteine and methionine and the facile thiol-yne reaction triggered by the propargyl sulfonium center.

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