An <em>Ex Vivo</em> Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices

V. Reed LaSala; Halil Beqaj; Mingze Sun; Sabrina Castagnini; Senay Ustunel; Elizabeth Cordoves; Kavya Rajesh; Sophia Jackman; David Kalfa

doi:10.3791/65885

Journal

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Bioengineering

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An Ex Vivo Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices

An <em>Ex Vivo</em> Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

An Ex Vivo Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices

An Ex Vivo Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices

936 Views

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06:56 min

•

August 25, 2023

DOI:

10.3791/65885-v

DOI:

10.3791/65885-v

•

06:56 min

August 25, 2023

•

902 Views

V. Reed LaSala¹, Halil Beqaj², Mingze Sun¹, Sabrina Castagnini³, Senay Ustunel¹, Elizabeth Cordoves², Kavya Rajesh², Sophia Jackman², David Kalfa^1,4

¹Department of Surgery,Columbia University Medical Center ²College of Physicians and Surgeons,Columbia University ³School of Medicine and Surgery,University of Bologna ⁴Division of Cardiac, Thoracic, and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New York-Presbyterian Morgan Stanley Children’s Hospital,Columbia University Medical Center

Summary

We present a method for mounting a porcine aortic valve on a pulse duplicator to test its hydrodynamic properties. This method can be used to determine the change in hydrodynamics after the application of an experimental procedure or novel medical device prior to use in a large animal model.