Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Our research involves leveraging our multimodal microscope to measure molecular and metabolic differences in several pathologies and visualize their spatial heterogeneity. The multimodal approach to optical imaging enables us to identify pathophysiological changes from a variety of perspectives. The multimodal approach to optical microscopy is continuously expanding its applications, particularly in the clinical setting, where the development of micro endoscopes has opened an avenue for clinical imaging.

The current experimental challenges lie in the complexity of incorporating all the hardware with one another, which is part of the reason why we utilize a custom-built microscope system. Through the use of our multimodal optical imaging platform, we have made significant strides in label-free bioorthogonal disease study, including the classification of different breast cancer subtypes and the analysis of lipid metabolism in the drosophila and mouse brain. Using our label-free multimodal optical imaging, we're able to visualize the metabolism, morphology, and molecular composition simultaneously, which is a powerful tool for investigating diseases and the aging process.