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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Bioengineering
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JoVE Journal Bioengineering
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

DOI:
10.3791/53769-v

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10:10 min

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August 15, 2016

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, , , , , , ,
1Department of Chemistry, Materials and Chemical Engineering “G. Natta”,Politecnico di Milano, 2Università degli studi e-Campus, 3ICRM,CNR – Consiglio Nazionale delle Ricerche, 4Elettra Sincrotrone Trieste, 5Department of Chemistry,University of Torino

Chapters

  • 00:05Title
  • 01:19Synthesis of Cyclodextrin Nanosponge Polymers
  • 03:36HR-MAS NMR Measurements
  • 07:05Results: How to Detect Variations of the Transport Properties of the Drug Encapsulated in the Hydrogel in Relation to the Nanosponge Synthesis
  • 08:50Conclusion

Summary

Automatic Translation

Automatic Translation

The motion regimes of ibuprofen encapsulated in β-cyclodextrin nanosponges polymer network are investigated using pulsed-field-gradient spin-echo (PGSE) NMR technique. Synthesis, purification, drug loading, implementation of the NMR pulse sequence and data analysis to work out the mean square displacement of the drug at several observation times are described in detail.

Tags

Cyclodextrin NanospongesHydrogelsIbuprofenTransport PropertiesHR-MAS NMR SpectroscopyDrug DeliveryStep-growth PolymerizationEDTA Dianhydride

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