Birgit Schilling Biography Publications JoVE Articles Birgit Schilling has not added a biography. If you are Birgit Schilling and would like to personalize this page please email our Author Liaison for assistance. Publications Cytotrophoblast Extracellular Vesicles Enhance Decidual Cell Secretion of Immune Modulators Via TNF-alpha Development (Cambridge, England). Aug, 2020 | Pubmed ID: 32747437 Translational Control of One-carbon Metabolism Underpins Ribosomal Protein Phenotypes in Cell Division and Longevity ELife. May, 2020 | Pubmed ID: 32432546 The Power of Proteomics to Monitor Senescence-associated Secretory Phenotypes and Beyond: Toward Clinical Applications Expert Review of Proteomics. Apr, 2020 | Pubmed ID: 32425074 Abundances of Transcripts, Proteins, and Metabolites in the Cell Cycle of Budding Yeast Reveal Coordinate Control of Lipid Metabolism Molecular Biology of the Cell. 05, 2020 | Pubmed ID: 32129706 Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics Journal of Proteome Research. Apr, 2020 | Pubmed ID: 31984744 Activating Transcription Factor 4 (ATF4) Promotes Skeletal Muscle Atrophy by Forming a Heterodimer with the Transcriptional Regulator C/EBPβ The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31953319 A Proteomic Atlas of Senescence-associated Secretomes for Aging Biomarker Development PLoS Biology. Jan, 2020 | Pubmed ID: 31945054 Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species Scientific Reports. Oct, 2019 | Pubmed ID: 31659173 Dietary Sugars Alter Hepatic Fatty Acid Oxidation Via Transcriptional and Post-translational Modifications of Mitochondrial Proteins Cell Metabolism. Oct, 2019 | Pubmed ID: 31577934 Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect Against AKI Journal of the American Society of Nephrology : JASN. Dec, 2019 | Pubmed ID: 31575700 SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells Cell Reports. Sep, 2019 | Pubmed ID: 31553904 Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity Proteomics. Aug, 2019 | Pubmed ID: 31408259 Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions Frontiers in Microbiology. 2019 | Pubmed ID: 31354686 High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31087289 Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation Molecular Cell. 05, 2019 | Pubmed ID: 31000437 Correction for Christensen Et Al., "Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli" MBio. 04, 2019 | Pubmed ID: 30967468 JNK Modifies Neuronal Metabolism to Promote Proteostasis and Longevity Aging Cell. 06, 2019 | Pubmed ID: 30810280 Global Lysine Acetylation in Results from Growth Conditions That Favor Acetate Fermentation Journal of Bacteriology. 05, 2019 | Pubmed ID: 30782634 Temporal Dynamics of Liver Mitochondrial Protein Acetylation and Succinylation and Metabolites Due to High Fat Diet And/or Excess Glucose or Fructose PloS One. 2018 | Pubmed ID: 30586434 Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli MBio. 10, 2018 | Pubmed ID: 30352934 Identifying Ubiquitinated Proteins and Aggregates Aging. 10, 2018 | Pubmed ID: 30335616 Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves MTOR Malonylation Cell Metabolism. 12, 2018 | Pubmed ID: 30146486 Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment Proteomics. 09, 2018 | Pubmed ID: 30035354 Removing 4E-BP Enables Synapses to Refine Without Postsynaptic Activity Cell Reports. 04, 2018 | Pubmed ID: 29617653 Protein Turnover in Aging and Longevity Proteomics. Mar, 2018 | Pubmed ID: 29453826 An Acetylatable Lysine Controls CRP Function in E. Coli Molecular Microbiology. Jan, 2018 | Pubmed ID: 29105190 Ancient Regulatory Role of Lysine Acetylation in Central Metabolism MBio. Nov, 2017 | Pubmed ID: 29184018 Characterization of Inner and Outer Membrane Proteins FromStrains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates MBio. Oct, 2017 | Pubmed ID: 29018123 Multi-laboratory Assessment of Reproducibility, Qualitative and Quantitative Performance of SWATH-mass Spectrometry Nature Communications. 08, 2017 | Pubmed ID: 28827567 PIQED: Automated Identification and Quantification of Protein Modifications from DIA-MS Data Nature Methods. Jun, 2017 | Pubmed ID: 28661500 Identification and Characterization of AckA-dependent Protein Acetylation in Neisseria Gonorrhoeae PloS One. 2017 | Pubmed ID: 28654654 MSstatsQC: Longitudinal System Suitability Monitoring and Quality Control for Targeted Proteomic Experiments Molecular & Cellular Proteomics : MCP. Jul, 2017 | Pubmed ID: 28483925 Clinical Applications of Quantitative Proteomics Using Targeted and Untargeted Data-independent Acquisition Techniques Expert Review of Proteomics. 05, 2017 | Pubmed ID: 28436239 Generation of High-Quality SWATHAcquisition Data for Label-free Quantitative Proteomics Studies Using TripleTOFMass Spectrometers Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28188533 Vitamin D Promotes Protein Homeostasis and Longevity Via the Stress Response Pathway Genes Skn-1, Ire-1, and Xbp-1 Cell Reports. 10, 2016 | Pubmed ID: 27783938 Stable Nuclear Expression of ATP8 and ATP6 Genes Rescues a MtDNA Complex V Null Mutant Nucleic Acids Research. Nov, 2016 | Pubmed ID: 27596602 Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH) Journal of the American Society for Mass Spectrometry. Nov, 2016 | Pubmed ID: 27590315 Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4 The Journal of Biological Chemistry. 08, 2016 | Pubmed ID: 27358404 Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss Neuron. 04, 2016 | Pubmed ID: 27041503 Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows Analytical Chemistry. Oct, 2015 | Pubmed ID: 26398777 Critical Role of Acetylation in Tau-mediated Neurodegeneration and Cognitive Deficits Nature Medicine. Oct, 2015 | Pubmed ID: 26390242 Protein Acetylation Dynamics in Response to Carbon Overflow in Escherichia Coli Molecular Microbiology. Dec, 2015 | Pubmed ID: 26264774 SIRT1 Deacetylates RORγt and Enhances Th17 Cell Generation The Journal of Experimental Medicine. May, 2015 | Pubmed ID: 25918343 Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma Molecular & Cellular Proteomics : MCP. Sep, 2015 | Pubmed ID: 25693799 Iron Promotes Protein Insolubility and Aging in C. Elegans Aging. Nov, 2014 | Pubmed ID: 25554795 Panorama: a Targeted Proteomics Knowledge Base Journal of Proteome Research. Sep, 2014 | Pubmed ID: 25102069 RPL24: a Potential Therapeutic Target Whose Depletion or Acetylation Inhibits Polysome Assembly and Cancer Cell Growth Oncotarget. Jul, 2014 | Pubmed ID: 24970821 Variation and Quantification Among a Target Set of Phosphopeptides in Human Plasma by Multiple Reaction Monitoring and SWATH-MS2 Data-independent Acquisition Electrophoresis. Dec, 2014 | Pubmed ID: 24853916 Structural, Kinetic and Proteomic Characterization of Acetyl Phosphate-dependent Bacterial Protein Acetylation PloS One. 2014 | Pubmed ID: 24756028 Phosphoprotein Secretome of Tumor Cells As a Source of Candidates for Breast Cancer Biomarkers in Plasma Molecular & Cellular Proteomics : MCP. Apr, 2014 | Pubmed ID: 24505115 Site-specific Acylation Changes in the Lipid A of Escherichia Coli LpxL Mutants Grown at High Temperatures Innate Immunity. Apr, 2014 | Pubmed ID: 23812252 Label-Free Quantitation and Mapping of the ErbB2 Tumor Receptor by Multiple Protease Digestion with Data-Dependent (MS1) and Data-Independent (MS2) Acquisitions International Journal of Proteomics. 2013 | Pubmed ID: 23710360 Label-free Quantitative Proteomics of the Lysine Acetylome in Mitochondria Identifies Substrates of SIRT3 in Metabolic Pathways Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23576753 Ligand Binding Promotes CDK-dependent Phosphorylation of ER-alpha on Hinge Serine 294 but Inhibits Ligand-independent Phosphorylation of Serine 305 Molecular Cancer Research : MCR. Aug, 2012 | Pubmed ID: 22669764 Ubiquitin-specific Peptidase 9, X-linked (USP9X) Modulates Activity of Mammalian Target of Rapamycin (mTOR) The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22544753 Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline: Application to Protein Acetylation and Phosphorylation Molecular & Cellular Proteomics : MCP. May, 2012 | Pubmed ID: 22454539 A Lectin Chromatography/mass Spectrometry Discovery Workflow Identifies Putative Biomarkers of Aggressive Breast Cancers Journal of Proteome Research. Feb, 2012 | Pubmed ID: 22309216 Mass Spectrometric Identification of Novel Lysine Acetylation Sites in Huntingtin Molecular & Cellular Proteomics : MCP. Oct, 2011 | Pubmed ID: 21685499 ScanRanker: Quality Assessment of Tandem Mass Spectra Via Sequence Tagging Journal of Proteome Research. Jul, 2011 | Pubmed ID: 21520941 Confident Identification of 3-nitrotyrosine Modifications in Mass Spectral Data Across Multiple Mass Spectrometry Platforms Journal of Proteomics. Oct, 2011 | Pubmed ID: 21514405 A Lectin Affinity Workflow Targeting Glycosite-specific, Cancer-related Carbohydrate Structures in Trypsin-digested Human Plasma Analytical Biochemistry. Jan, 2011 | Pubmed ID: 20705048 Identification of New Modulators and Protein Alterations in Non-apoptotic Programmed Cell Death Journal of Cellular Biochemistry. Dec, 2010 | Pubmed ID: 20830744 Targeted Quantitation of Site-specific Cysteine Oxidation in Endogenous Proteins Using a Differential Alkylation and Multiple Reaction Monitoring Mass Spectrometry Approach Molecular & Cellular Proteomics : MCP. Jul, 2010 | Pubmed ID: 20233844 Repeatability and Reproducibility in Proteomic Identifications by Liquid Chromatography-tandem Mass Spectrometry Journal of Proteome Research. Feb, 2010 | Pubmed ID: 19921851 Interlaboratory Study Characterizing a Yeast Performance Standard for Benchmarking LC-MS Platform Performance Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19858499 Performance Metrics for Liquid Chromatography-tandem Mass Spectrometry Systems in Proteomics Analyses Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19837981 The Mycobacterium Bovis Bacille Calmette-Guerin Phagosome Proteome Molecular & Cellular Proteomics : MCP. Jan, 2010 | Pubmed ID: 19815536 Preferentially Increased Nitration of Alpha-synuclein at Tyrosine-39 in a Cellular Oxidative Model of Parkinson's Disease Analytical Chemistry. Sep, 2009 | Pubmed ID: 19697948 Multi-site Assessment of the Precision and Reproducibility of Multiple Reaction Monitoring-based Measurements of Proteins in Plasma Nature Biotechnology. Jul, 2009 | Pubmed ID: 19561596 IDPicker 2.0: Improved Protein Assembly with High Discrimination Peptide Identification Filtering Journal of Proteome Research. Aug, 2009 | Pubmed ID: 19522537 Systematic Mapping of Posttranslational Modifications in Human Estrogen Receptor-alpha with Emphasis on Novel Phosphorylation Sites Molecular & Cellular Proteomics : MCP. Mar, 2009 | Pubmed ID: 18984578 A Novel Serine Phosphorylation Site Detected in the N-terminal Domain of Estrogen Receptor Isolated from Human Breast Cancer Cells Journal of the American Society for Mass Spectrometry. May, 2008 | Pubmed ID: 18367407 Partial Acetylation of Lysine Residues Improves Intraprotein Cross-linking Analytical Chemistry. Feb, 2008 | Pubmed ID: 18201069 Identification of LpxL, a Late Acyltransferase of Francisella Tularensis Infection and Immunity. Nov, 2007 | Pubmed ID: 17724076 Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau PloS One. 2007 | Pubmed ID: 17579710 Small-scale Immunopurification of Cytochrome C Oxidase for a High-throughput Multiplexing Analysis of Enzyme Activity and Amount Biotechnology and Applied Biochemistry. Dec, 2007 | Pubmed ID: 17508937 Characterization of Lipid A Acylation Patterns in Francisella Tularensis, Francisella Novicida, and Francisella Philomiragia Using Multiple-stage Mass Spectrometry and Matrix-assisted Laser Desorption/ionization on an Intermediate Vacuum Source Linear Ion Trap Analytical Chemistry. Feb, 2007 | Pubmed ID: 17263332 Novel Pathways Associated with Quinone-induced Stress in Breast Cancer Cells Drug Metabolism Reviews. 2006 | Pubmed ID: 17145690 Huntingtin Phosphorylation Sites Mapped by Mass Spectrometry. Modulation of Cleavage and Toxicity The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16782707 Proteomic Analysis of Succinate Dehydrogenase and Ubiquinol-cytochrome C Reductase (Complex II and III) Isolated by Immunoprecipitation from Bovine and Mouse Heart Mitochondria Biochimica Et Biophysica Acta. Feb, 2006 | Pubmed ID: 16120479 A Pilot Proteomic Study of Amyloid Precursor Interactors in Alzheimer's Disease Annals of Neurology. Aug, 2005 | Pubmed ID: 16049941 Mass Spectrometric Identification of a Novel Phosphorylation Site in Subunit NDUFA10 of Bovine Mitochondrial Complex I FEBS Letters. Apr, 2005 | Pubmed ID: 15848193 Rapid Purification and Mass Spectrometric Characterization of Mitochondrial NADH Dehydrogenase (Complex I) from Rodent Brain and a Dopaminergic Neuronal Cell Line Molecular & Cellular Proteomics : MCP. Jan, 2005 | Pubmed ID: 15591592 Novel Modification of Lipid A of Francisella Tularensis Infection and Immunity. Sep, 2004 | Pubmed ID: 15322031 A Novel Lectin, DltA, is Required for Expression of a Full Serum Resistance Phenotype in Haemophilus Ducreyi Infection and Immunity. Jun, 2004 | Pubmed ID: 15155648 Proteomic and Immunochemical Characterization of a Role for Stathmin in Adult Neurogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2004 | Pubmed ID: 14769823 Molecular Components of a Cell Death Pathway Activated by Endoplasmic Reticulum Stress The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14561754 Isotopically Labeled Crosslinking Reagents: Resolution of Mass Degeneracy in the Identification of Crosslinked Peptides Bioorganic & Medicinal Chemistry Letters. Nov, 2003 | Pubmed ID: 14592499 Phosphospecific Proteolysis for Mapping Sites of Protein Phosphorylation Nature Biotechnology. Sep, 2003 | Pubmed ID: 12923550 MS2Assign, Automated Assignment and Nomenclature of Tandem Mass Spectra of Chemically Crosslinked Peptides Journal of the American Society for Mass Spectrometry. Aug, 2003 | Pubmed ID: 12892908 Cathepsin L in Secretory Vesicles Functions As a Prohormone-processing Enzyme for Production of the Enkephalin Peptide Neurotransmitter Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12869695 Metabolic Incorporation of Unnatural Sialic Acids into Haemophilus Ducreyi Lipooligosaccharides Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12615992 Characterization of Lipooligosaccharides from Haemophilus Ducreyi Containing Polylactosamine Repeats Journal of the American Society for Mass Spectrometry. Jun, 2002 | Pubmed ID: 12056572 Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology إثراء التقارب المتزامن لتعديلات ما بعد الترجمة للقياس الكمي وتوطين الموقع Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology التحديد الكمي للبروتين خاصة بالموقع يسين Acetylation و Succinylation Stoichiometry الكتلي حيازة مستقلة عن البيانات باستخدام Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology وهناك طريقة HPLC Lectin لإثراء هضميدات انتقائية الغليكوزيلاتي من العينات البيولوجية المعقدة Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology
إثراء التقارب المتزامن لتعديلات ما بعد الترجمة للقياس الكمي وتوطين الموقع Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology
التحديد الكمي للبروتين خاصة بالموقع يسين Acetylation و Succinylation Stoichiometry الكتلي حيازة مستقلة عن البيانات باستخدام Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology
وهناك طريقة HPLC Lectin لإثراء هضميدات انتقائية الغليكوزيلاتي من العينات البيولوجية المعقدة Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology
