Melinda Wuest Department of Oncology University of Alberta Biography Publications Institution JoVE Articles Melinda Wuest has not added a biography. If you are Melinda Wuest and would like to personalize this page please email our Author Liaison for assistance. Publications Radiosynthesis and Biological Evaluation of [F]Triacoxib: A New Radiotracer for PET Imaging of COX-2 Molecular Pharmaceutics. Jan, 2020 | Pubmed ID: 31816246 Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Molecular Cancer Therapeutics. Jan, 2020 | Pubmed ID: 31548293 Radiometal-Containing Aryl Diazonium Salts for Chemoselective Bioconjugation of Tyrosine Residues ACS Omega. Dec, 2019 | Pubmed ID: 31891090 Comparison of Scandium-44 g with Other PET Radionuclides in Pre-clinical PET Phantom Imaging EJNMMI Physics. Dec, 2019 | Pubmed ID: 31832809 Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle Cancers. Nov, 2019 | Pubmed ID: 31752313 Effect of Hypoxia on Human Equilibrative Nucleoside Transporters HENT1 and HENT2 in Breast Cancer FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2019 | Pubmed ID: 31601121 Targeting Phosphatidylserine for Radionuclide-based Molecular Imaging of Apoptosis Apoptosis : an International Journal on Programmed Cell Death. 04, 2019 | Pubmed ID: 30684144 Expression and Function of Hexose Transporters GLUT1, GLUT2, and GLUT5 in Breast Cancer-effects of Hypoxia FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 09, 2018 | Pubmed ID: 29913554 Impact of Structural Alterations on the Radiopharmacological Profile of F-labeled Pyrimidines As Cyclooxygenase-2 (COX-2) Imaging Agents Nuclear Medicine and Biology. Jul - Aug, 2018 | Pubmed ID: 29800798 Positron Emission Tomography (PET) and Pharmacokinetics: Classical Blood Sampling Versus Image-Derived Analysis of [18F]FAZA and [18F]FDG in a Murine Tumor Bearing Model Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques. 2018 | Pubmed ID: 29702045 Molecular Imaging of Platelet-derived Growth Factor Receptor-alpha (PDGFRα) in Papillary Thyroid Cancer Using Immuno-PET Nuclear Medicine and Biology. 03, 2018 | Pubmed ID: 29367096 F-Radiolabeling and In Vivo Analysis of SiFA-Derivatized Polymeric Core-Shell Nanoparticles Bioconjugate Chemistry. 01, 2018 | Pubmed ID: 29202229 Molecular Imaging of GLUT1 and GLUT5 in Breast Cancer: A Multitracer Positron Emission Tomography Imaging Study in Mice Molecular Pharmacology. 02, 2018 | Pubmed ID: 29142019 Targeting Prostate-Specific Membrane Antigen (PSMA) with F-18-Labeled Compounds: the Influence of Prosthetic Groups on Tumor Uptake and Clearance Profile Molecular Imaging and Biology. 12, 2017 | Pubmed ID: 28639122 Proteomic Characterization of EL4 Lymphoma-derived Tumors Upon Chemotherapy Treatment Reveals Potential Roles for Lysosomes and Caspase-6 During Tumor Cell Death in Vivo Proteomics. Jun, 2017 | Pubmed ID: 28508578 In Situ Click Chemistry Generation of Cyclooxygenase-2 Inhibitors Nature Communications. 02, 2017 | Pubmed ID: 28232747 Targeting Phosphatidylserine with a Cu-Labeled Peptide for Molecular Imaging of Apoptosis Molecular Pharmaceutics. 10, 2016 | Pubmed ID: 27608290 Synthesis and Pre-clinical Evaluation of an (18)F-labeled Single-chain Antibody Fragment for PET Imaging of Epithelial Ovarian Cancer American Journal of Nuclear Medicine and Molecular Imaging. 2016 | Pubmed ID: 27508105 Automated Synthesis of [(18)F]DCFPyL Via Direct Radiofluorination and Validation in Preclinical Prostate Cancer Models EJNMMI Research. Dec, 2016 | Pubmed ID: 27142881 PET Imaging of Cyclooxygenase-2 (COX-2) in a Pre-clinical Colorectal Cancer Model EJNMMI Research. Dec, 2016 | Pubmed ID: 27112768 Metabolically Stabilized (68)Ga-NOTA-Bombesin for PET Imaging of Prostate Cancer and Influence of Protease Inhibitor Phosphoramidon Molecular Pharmaceutics. Apr, 2016 | Pubmed ID: 26973098 Design, Synthesis, and Evaluation of an (18)F-Labeled Radiotracer Based on Celecoxib-NBD for Positron Emission Tomography (PET) Imaging of Cyclooxygenase-2 (COX-2) ChemMedChem. Oct, 2015 | Pubmed ID: 26287271 Targeting Lysyl Oxidase for Molecular Imaging in Breast Cancer Breast Cancer Research : BCR. Aug, 2015 | Pubmed ID: 26265048 Radiopharmacological Evaluation of (18)F-labeled Phosphatidylserine-binding Peptides for Molecular Imaging of Apoptosis Nuclear Medicine and Biology. Nov, 2015 | Pubmed ID: 26205076 Erratum: Automated Synthesis and Dosimetry of 6-deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF): a Radiotracer for Imaging of GLUT5 in Breast Cancer American Journal of Nuclear Medicine and Molecular Imaging. 2015 | Pubmed ID: 25625031 Rerouting the Metabolic Pathway of (18)F-labeled Peptides: the Influence of Prosthetic Groups Bioconjugate Chemistry. Feb, 2015 | Pubmed ID: 25572982 Immuno-PET of Epithelial Ovarian Cancer: Harnessing the Potential of CA125 for Non-invasive Imaging EJNMMI Research. Dec, 2014 | Pubmed ID: 26116121 Detecting Functional Changes with [(18)F]FAZA in a Renal Cell Carcinoma Mouse Model Following Sunitinib Therapy EJNMMI Research. Dec, 2014 | Pubmed ID: 26116107 Synthesis and Evaluation of 2-amino-5-(4-[(18)F]fluorophenyl)pent-4-ynoic Acid ([(18)F]FPhPA): a Novel (18)F-labeled Amino Acid for Oncologic PET Imaging Nuclear Medicine and Biology. Sep, 2014 | Pubmed ID: 24993371 Automated Synthesis and Dosimetry of 6-deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF): a Radiotracer for Imaging of GLUT5 in Breast Cancer American Journal of Nuclear Medicine and Molecular Imaging. 2014 | Pubmed ID: 24795839 Positron Emission Tomography Radiotracers for Imaging Hypoxia Journal of Labelled Compounds & Radiopharmaceuticals. Mar-Apr, 2013 | Pubmed ID: 24285331 Synthesis of Three 18F-labelled Cyclooxygenase-2 (COX-2) Inhibitors Based on a Pyrimidine Scaffold Organic & Biomolecular Chemistry. Dec, 2013 | Pubmed ID: 24145766 Synthesis and Radiopharmacological Evaluation of a High-affinity and Metabolically Stabilized 18F-labeled Bombesin Analogue for Molecular Imaging of Gastrin-releasing Peptide Receptor-expressing Prostate Cancer Nuclear Medicine and Biology. Nov, 2013 | Pubmed ID: 23969085 Synthesis, Characterisation and Evaluation of a Novel Copper-64 Complex with Selective Uptake in EMT-6 Cells Under Hypoxic Conditions Dalton Transactions (Cambridge, England : 2003). Jul, 2013 | Pubmed ID: 23838751 Synthesis and Evaluation of an 18F-labelled Norbornene Derivative for Copper-free Click Chemistry Reactions Organic & Biomolecular Chemistry. Jun, 2013 | Pubmed ID: 23640655 Comparative Functional Evaluation of Immunocompetent Mouse Breast Cancer Models Established from PyMT-tumors Using Small Animal PET with [(18)F]FDG and [(18)F]FLT American Journal of Nuclear Medicine and Molecular Imaging. 2012 | Pubmed ID: 23133804 In Vitro and in Vivo Evaluation of [(18)F]F-GAZ, a Novel Oxygen-mimetic Azomycin-glucose Conjugate, for Imaging Hypoxic Tumor Cancer Biotherapy & Radiopharmaceuticals. Oct, 2012 | Pubmed ID: 22746267 Synthesis and Evaluation of Fluorobenzoylated Di- and Tripeptides As Inhibitors of Cyclooxygenase-2 (COX-2) Bioorganic & Medicinal Chemistry. Apr, 2012 | Pubmed ID: 22386983 Microfluidic Technology: an Economical and Versatile Approach for the Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) Bioorganic & Medicinal Chemistry Letters. Mar, 2012 | Pubmed ID: 22342141 Copper-free Click Chemistry with the Short-lived Positron Emitter Fluorine-18 Organic & Biomolecular Chemistry. Nov, 2011 | Pubmed ID: 21938294 Radiopharmacological Evaluation of 6-deoxy-6-[18F]fluoro-D-fructose As a Radiotracer for PET Imaging of GLUT5 in Breast Cancer Nuclear Medicine and Biology. May, 2011 | Pubmed ID: 21531283 The Muscarinic Receptor Antagonist Propiverine Exhibits α(1)-adrenoceptor Antagonism in Human Prostate and Porcine Trigonum World Journal of Urology. Apr, 2011 | Pubmed ID: 21336600 Synthesis of Hypoxia Imaging Agent 1-(5-deoxy-5-fluoro-α-D-arabinofuranosyl)-2-nitroimidazole Using Microfluidic Technology Nuclear Medicine and Biology. Feb, 2011 | Pubmed ID: 21315279 Biodistribution and Uptake of 3'-deoxy-3'-fluorothymidine in ENT1-knockout Mice and in an ENT1-knockdown Tumor Model Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Sep, 2010 | Pubmed ID: 20720035 18 F-labeling van Radiotracers Functionaliseerde met een Siliciumfluoride acceptor (SiFA) voor positron emissie tomografie David Connolly*1, Justin J. Bailey*1, Harun Ilhan2,3, Peter Bartenstein2,3, Carmen Wängler4, Björn Wängler5, Melinda Wuest1, Frank Wuest1, Ralf Schirrmacher1 1Department of Oncology, University of Alberta, 2Department of Nuclear Medicine, University Hospital of Munich, 3ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, LMU Munich, 4Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, 5Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University JoVE 60623 Chemistry
18 F-labeling van Radiotracers Functionaliseerde met een Siliciumfluoride acceptor (SiFA) voor positron emissie tomografie David Connolly*1, Justin J. Bailey*1, Harun Ilhan2,3, Peter Bartenstein2,3, Carmen Wängler4, Björn Wängler5, Melinda Wuest1, Frank Wuest1, Ralf Schirrmacher1 1Department of Oncology, University of Alberta, 2Department of Nuclear Medicine, University Hospital of Munich, 3ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, LMU Munich, 4Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, 5Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University JoVE 60623 Chemistry