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JoVE Clinical and Translational Medicine
JoVE Clinical and Translational Medicine serves as a connection between basic research and clinical applications. Articles may present medical procedures, case studies or clinical trial methodologies. Included studies are often modeled towards predictive, preventative, personalized, and practical approaches to treatment of disease. The goal of research methodologies in this section is to improve overall patient care and prognosis.
 JoVE Clinical and Translational Medicine

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

1Department of Surgery, University Medical Center Groningen, 2Helmholtz Zentrum Munich, Technical University of Munich


JoVE 51776

Near-infrared fluorescence (NIRF) imaging may improve therapeutic outcome of breast cancer surgery by enabling intraoperative tumor localization and evaluation of surgical margin status. Using tissue-simulating breast phantoms containing fluorescent tumor-simulating inclusions, potential clinical applications of NIRF imaging in breast cancer patients can be assessed for standardization and training purposes.

 JoVE Clinical and Translational Medicine

Embolic Middle Cerebral Artery Occlusion (MCAO) for Ischemic Stroke with Homologous Blood Clots in Rats

1Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Science Center


JoVE 51956

In this paper, we demonstrate a standard method for producing an embolic middle cerebral artery occlusion with homologous blood clots (fibrin-rich) in adult rat. This model closely mimics human ischemic stroke and is suitable for preclinical study of thrombolytic therapy for ischemic stroke.

 JoVE Clinical and Translational Medicine

Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty

1Department of Ophthalmology, University of Michigan, 2MidWest Eye Banks


JoVE 51919

Endothelial keratoplasty is a surgical technique continuously evolving as advancements result in transplantation of thinner grafts with each succession1. Here we present a technique for controlled manual tissue dissection to allow safe and repeatable separation of endothelium and Descemet's membranes from donor corneoscleral buttons for transplantation2.

 JoVE Clinical and Translational Medicine

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

1Biotechnology and Applied Clinical Sciences Department, University of L'Aquila, 2ARC Centre of Excellence in Vision Science, 3John Curtin School of Medical Research, Australian National University, 4ANU Medical School, Australian National University


JoVE 51563

This paper details how Elvax 40W can be used as a slow-release method for drug delivery to the adult rat retina. The protocol for preparing, loading, and delivering the drug-resin complex to the eye is described.

 JoVE Clinical and Translational Medicine

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

1European Vascular Center Aachen-Maastricht, Department of Vascular Surgery, University Hospital RWTH Aachen


JoVE 51115

Auxiliary liver transplantation provides a temporary support in acute hepatic failure, until regeneration of the failing liver. The heterotopic auxiliary liver transplantation (HALT) with portal vein arterialization (PVA) renders sufficient liver function. We developed an analogous technique in the rat, to examine the influence of the portal vein arterialization on the morphology and function of the graft.

 JoVE Clinical and Translational Medicine

Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines

1Department of Biochemistry and Molecular Biology, Indiana University School of Medicine


JoVE 51891

Cancer stem cells (CSCs) are implicated in tumor relapse due to chemoresistance. We have optimized a protocol for selection and expansion of CSCs from ovarian cancer cell lines. By treating cells with the chemotherapeutic cisplatin and culturing in a stem cell promoting media we enrich for non-adherent CSC cultures.

 JoVE Clinical and Translational Medicine

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

1Human Performance Laboratory, North Carolina Research Campus, Appalacian State University, 2College of Health Sciences, Appalachian State University, 3Department of Emergency Medicine, Carolinas Medical Center NorthEast


JoVE 51812

The purpose of this video is to present the modified Bergström skeletal muscle biopsy technique on human subjects.

 JoVE Clinical and Translational Medicine

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

1Departamento de Desarrollo Biotecnológico, Universidad de la República, *Present Affiliation: Trinity Biomedical Science Institute, Trinity College Dublin


JoVE 52036

The present work illustrates the convenience of using sublingual immunotherapy to boost the innate immune response in the lungs and confer protection against acute pneumococcal pneumonia in mouse.

 JoVE Clinical and Translational Medicine

Collection and Extraction of Saliva DNA for Next Generation Sequencing

1Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, 2The Interdisciplinary Graduate Program in Biophysics, The Ohio State University, 3Department of Pediatrics, The Ohio State University


JoVE 51697

DNA extraction from saliva can provide a readily available source of high molecular weight DNA, with little to no degradation/fragmentation. This protocol provides optimized parameters for saliva collection/storage and DNA extraction to be of sufficient quality and quantity for downstream DNA assays with high quality requirements.

 JoVE Clinical and Translational Medicine

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

1National Service of Neurosurgery, Centre Hospitalier de Luxembourg, 2University of Applied Sciences Trier, 3Internal Medicine, Erasmus Universiteit Rotterdam, 4Service of Neuroradiology, Centre Hospitalier de Luxembourg


JoVE 51946

Diffusion tensor imaging (DTI) was performed to try to depict the major parts of the visual pathway. The goal was to use an FDA approved standard commercial workstation which could be used for everyday routine in order to try to reduce postoperative damage of the visual pathway in the patients.

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