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JoVE Clinical and Translational Medicine
JoVE Clinical and Translational Medicine serves as a connection between basic research and clinical applications. Articles may present medical procedures, case studies or clinical trial methodologies. Included studies are often modeled towards predictive, preventative, personalized, and practical approaches to treatment of disease. The goal of research methodologies in this section is to improve overall patient care and prognosis.
 JoVE Clinical and Translational Medicine

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

1European Vascular Center Aachen-Maastricht, Department of Vascular Surgery, University Hospital RWTH Aachen


JoVE 51115

Auxiliary liver transplantation provides a temporary support in acute hepatic failure, until regeneration of the failing liver. The heterotopic auxiliary liver transplantation (HALT) with portal vein arterialization (PVA) renders sufficient liver function. We developed an analogous technique in the rat, to examine the influence of the portal vein arterialization on the morphology and function of the graft.

 JoVE Clinical and Translational Medicine

Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines

1Department of Biochemistry and Molecular Biology, Indiana University School of Medicine


JoVE 51891

Cancer stem cells (CSCs) are implicated in tumor relapse due to chemoresistance. We have optimized a protocol for selection and expansion of CSCs from ovarian cancer cell lines. By treating cells with the chemotherapeutic cisplatin and culturing in a stem cell promoting media we enrich for non-adherent CSC cultures.

 JoVE Clinical and Translational Medicine

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

1Human Performance Laboratory, North Carolina Research Campus, Appalacian State University, 2College of Health Sciences, Appalachian State University, 3Department of Emergency Medicine, Carolinas Medical Center NorthEast


JoVE 51812

The purpose of this video is to present the modified Bergström skeletal muscle biopsy technique on human subjects.

 JoVE Clinical and Translational Medicine

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

1Departamento de Desarrollo Biotecnológico, Universidad de la República, *Present Affiliation: Trinity Biomedical Science Institute, Trinity College Dublin


JoVE 52036

The present work illustrates the convenience of using sublingual immunotherapy to boost the innate immune response in the lungs and confer protection against acute pneumococcal pneumonia in mouse.

 JoVE Clinical and Translational Medicine

Collection and Extraction of Saliva DNA for Next Generation Sequencing

1Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, 2The Interdisciplinary Graduate Program in Biophysics, The Ohio State University, 3Department of Pediatrics, The Ohio State University


JoVE 51697

DNA extraction from saliva can provide a readily available source of high molecular weight DNA, with little to no degradation/fragmentation. This protocol provides optimized parameters for saliva collection/storage and DNA extraction to be of sufficient quality and quantity for downstream DNA assays with high quality requirements.

 JoVE Clinical and Translational Medicine

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

1National Service of Neurosurgery, Centre Hospitalier de Luxembourg, 2University of Applied Sciences Trier, 3Internal Medicine, Erasmus Universiteit Rotterdam, 4Service of Neuroradiology, Centre Hospitalier de Luxembourg


JoVE 51946

Diffusion tensor imaging (DTI) was performed to try to depict the major parts of the visual pathway. The goal was to use an FDA approved standard commercial workstation which could be used for everyday routine in order to try to reduce postoperative damage of the visual pathway in the patients.

 JoVE Clinical and Translational Medicine

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

1Department of Medicine B, University Hospital Münster, 2Department of Pediatric Rheumatology and Immunology, University Children's Hospital Münster


JoVE 51875

Small animal imaging techniques allow serial diagnostic examinations and therapeutic interventions in vivo. Recently, the scope of applications has significantly widened and currently includes assessment of colonic tumor development, wound healing and monitoring of inflammation. This protocol illustrates these diverse potential applications of murine endoscopy.

 JoVE Clinical and Translational Medicine

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

1Department of Medicine, Renal division, University of Pittsburgh School of Medicine, 2Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine


JoVE 51807

This manuscript presents a simple, yet powerful, in vitro method for evaluating smooth muscle contractility in response to pharmacological agents or nerve stimulation. Main applications are drug screening and understanding tissue physiology, pharmacology, and pathology.

 JoVE Clinical and Translational Medicine

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

1Multi Organ Transplant Program, Toronto General Hospital, 2Department of Surgery, Toronto General Hospital, 3Department of Medicine, Toronto General Hospital


JoVE 51419

Marginal grafts, such as fatty livers, grafts from older donors, or livers retrieved after cardiac death (DCD) tolerate conventional, cold static storage only poorly. We developed a novel model of subnormothermic ex vivo liver perfusion for preservation, assessment, and repair of marginal liver grafts prior to transplantation.

 JoVE Clinical and Translational Medicine

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

1Department of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, University of Pennsylvania


JoVE 51653

These studies report on reversible attachment of adenoviral gene vectors to coatless metal surfaces of stents and model mesh disks. Sustained release of transduction-competent viral particles contingent upon hydrolysis of cross-linkers used for vector immobilization results in a durable site-specific transgene expression in vascular cells and in stented arteries.

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