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JoVE Clinical and Translational Medicine
JoVE Clinical and Translational Medicine serves as a connection between basic research and clinical applications. Articles may present medical procedures, case studies or clinical trial methodologies. Included studies are often modeled towards predictive, preventative, personalized, and practical approaches to treatment of disease. The goal of research methodologies in this section is to improve overall patient care and prognosis.
 JoVE Clinical and Translational Medicine

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

1MRC Centre for Inflammation Research, University of Edinburgh


JoVE 52559

The murine model of irreversible unilateral ureteric obstruction (UUO) is presented together with the model of reversible UUO in which the ureteric obstruction is relieved by anastomosis of the severed ureter into the bladder. These models enable the study of renal inflammation and scarring as well as tissue remodeling.

 JoVE Clinical and Translational Medicine

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine


JoVE 52306

Non-invasive imaging of the brain vasculature’s ability to dilate or constrict may allow a better understanding of cerebrovascular pathophysiology in various neurological diseases. The present report describes a reproducible and patient-comfortable protocol to perform vascular reactivity imaging in humans using magnetic resonance imaging (MRI).

 JoVE Clinical and Translational Medicine

Mouse Pneumonectomy Model of Compensatory Lung Growth

1Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center


JoVE 52294

Mouse pneumonectomy is a commonly employed model of compensatory lung growth. This procedure can be used in conjunction with lineage tracing or transgenic mouse models to elucidate underlying mechanisms.

 JoVE Clinical and Translational Medicine

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

1Laboratory of Pharmacology, Department of Health Sciences, University of Milan, 2Department of Neuroscience, College of Medicine, The Ohio State University


JoVE 52141

Spinal cord injury is a traumatic condition that causes severe morbidity and high mortality. In this work we describe in detail a contusion model of spinal cord injury in mice followed by a transplantation of neural stem cells.

 JoVE Clinical and Translational Medicine

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

1Department of Biological Regulation, Weizmann Institute of Science, 2Unit of Biological Services, Weizmann Institute of Science, 3Department of Diagnostic Imaging, Meir Medical Center, 4Pathology Department, Meir Medical Center


JoVE 52048

We describe how to obtain parametric and vector maps of the diffusion tensor of the breast using magnetic resonance imaging. The protocol and final output following imaging processing are tailored for tracking breast architectural features and detecting breast malignancy.

 JoVE Clinical and Translational Medicine

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

1Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women‘s Hospital


JoVE 52154

Fecal Microbiota Transplantation via colonoscopy is a safe and effective treatment for recurrent and refractory C.difficile infection. A systematic approach to patient and donor screening, preparation of stool, and delivery of the stool during the colonoscopy will maximize therapeutic success.

 JoVE Clinical and Translational Medicine

A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

1Department of Exercise Science, Elon University, 2Department of Physical Therapy Education, Elon University, 3Department of Physical Therapy, Duquesne University, 4Department of Sports Medicine, Elon University


JoVE 52046

There is great variability in an individual’s risk for concussion and their corresponding recovery. A multifaceted approach to concussion evaluation is warranted; including baseline testing of athletes before participation in sport and timely evaluation post injury. The goal of this protocol is to provide an appropriate multifaceted approach to examine concussions.

 JoVE Clinical and Translational Medicine

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats

1Alberta Children's Hospital Research Institute, University of Calgary, 2Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine & John D. Dingell VA Medical Center


JoVE 51820

The modified weight-drop technique is an easy, cost-effective procedure used for the induction of mild traumatic brain injury in juvenile rats. This novel technique produces clinically relevant symptomology that will advance the study of mild traumatic brain injury (mTBI) and concussion.

 JoVE Clinical and Translational Medicine

Localization, Identification, and Excision of Murine Adipose Depots

1Department of Emergency Medicine, University of Cincinnati College of Medicine


JoVE 52174

Due to the drastic and negative connection between obesity and other comorbidities, research on the role adipose plays in disease and overall health is warranted. We present a protocol for the isolation and excision of adipose depots allowing for the study of adipose using in situ and in vitro methods.

 JoVE Clinical and Translational Medicine

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

1Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, Catholic University of Leuven


JoVE 52206

Heart failure is the leading cause of hospitalization and a major cause of mortality. A model of permanent ligation of the left anterior descending coronary artery in mice is applied to investigate ventricular remodelling and cardiac dysfunction post-myocardial infarction. The technique of invasive hemodynamic measurements in mice is presented.

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