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JoVE Clinical and Translational Medicine
JoVE Clinical and Translational Medicine serves as a connection between basic research and clinical applications. Articles may present medical procedures, case studies or clinical trial methodologies. Included studies are often modeled towards predictive, preventative, personalized, and practical approaches to treatment of disease. The goal of research methodologies in this section is to improve overall patient care and prognosis.
 JoVE Clinical and Translational Medicine

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

1Tissue Engineering Program and Surgical Research, Nationwide Children's Hospital, 2Cardiothoracic Surgery, Nationwide Children's Hospital, 3Pediatric Surgery, Nationwide Children's Hospital


JoVE 51695

In order to understand the cellular and molecular mechanisms underlying neotissue formation and stenosis development in tissue engineered heart valves, a murine model of heterotopic heart valve transplantation was developed. A pulmonary heart valve was transplanted to recipient using the heterotopic heart transplantation technique.

 JoVE Clinical and Translational Medicine

Shrinkage of Dental Composite in Simulated Cavity Measured with Digital Image Correlation

1Minnesota Dental Research Center for Biomaterials and Biomechanics, School of Dentistry, University of Minnesota


JoVE 51191

In order to understand the spatial development of polymerization shrinkage stress in dental resin-composite restorations, Digital Image Correlation was used to provide full-field displacement/strain measurement of restored model glass cavities by correlating images of the restoration taken before and after polymerization.

 JoVE Clinical and Translational Medicine

Primary Culture of Human Vestibular Schwannomas

1Department of Otolaryngology–Head and Neck, University of Iowa Hospitals and Clinics


JoVE 51093

Vestibular Schwannomas (VSs) are non-malignant tumors of Schwann cell (SC) origin, associated with mutations in the NF2 tumor suppressor gene. We report a reproducible, efficient protocol for primary human VS cell culture that allows for molecular and cellular experimental manipulation and analysis and recapitulates the heterogeneous nature of human disease.

 JoVE Clinical and Translational Medicine

Implantation of Total Artificial Heart in Congenital Heart Disease

1Congenital Heart Surgery, Texas Children's Hospital, 2Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 3Cincinnati Children's Hospital Medical Center, The University of Cincinnati College of Medicine


JoVE 51569

This is a case report of a patient with congenitally corrected transposition of the great arteries (CCTGA) who received a total artificial heart (TAH) as a bridge to heart transplant. The TAH was successfully implanted with modifications to accommodate the patient's congenitally malformed heart.

 JoVE Clinical and Translational Medicine

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

1Institut des Neurosciences Cellulaires et Intégratives UPR3212, Centre National de la Recherche Scientifique, 2Université de Strasbourg, 3Hôpitaux Universitaires de Strasbourg


JoVE 51608

Neuropathic pain is a consequence of a lesion or disease affecting the somatosensory system. The “cuff model” of neuropathic pain in mice consists of the implantation of a polyethylene cuff around the main branch of the sciatic nerve. Mechanical allodynia is tested using von Frey filaments.

 JoVE Clinical and Translational Medicine

Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

1Department of Biomedical Engineering, Boston University, 2Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School


JoVE 51452

A mouse model of human endoscopic skull base reconstruction has been developed that creates a semipermeable interface between the brain and nose using nasal mucosal grafts. This method allows researchers to study delivery to the central nervous system of high molecular weight therapeutics which are otherwise excluded by the blood-brain barrier when administered systemically.

 JoVE Clinical and Translational Medicine

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

1Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, 2Sobell Department of Motor Neuroscience & Movement Disorders, Unit of Functional Neurosurgery, UCL Institute of Neurology


JoVE 51403

Adaptive deep brain stimulation (aDBS) is effective for Parkinson’s disease, improving symptoms and reducing power consumption compared to conventional deep brain stimulation (cDBS). In aDBS we track a local field potential biomarker (beta oscillatory amplitude) in real time and use this to control the timing of stimulation.

 JoVE Clinical and Translational Medicine

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

1Department of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center


JoVE 51839

We demonstrate the construction of alcohol vapor chambers using readily available materials that simultaneously house 6 mouse cages. We further describe their use in a mouse model of fetal alcohol exposure equivalent to all 3 trimesters of human pregnancy. This paradigm exposes animals during gestation and postnatal days 1-12.

 JoVE Clinical and Translational Medicine

Murine Heterotopic Heart Transplant Technique

1Colorado Center for Transplantation Care, Research and Education and Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver


JoVE 51511

The manuscript describes the steps required to perform the heterotopic heart transplant in the mouse.

 JoVE Clinical and Translational Medicine

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples

1Department of Medical Microbiology, University of Manitoba, 2Department of Community Health Sciences, University of Manitoba


JoVE 51906

The use of cytobrush sampling to collect lymphocytes and monocytes from the endocervix is a minimally invasive technique that provides samples for analysis of female genital tract immunity. In this protocol, we describe the collection of cytobrush samples and immune cell isolation for flow cytometry assays.

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