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JoVE Clinical and Translational Medicine
JoVE Clinical and Translational Medicine serves as a connection between basic research and clinical applications. Articles may present medical procedures, case studies or clinical trial methodologies. Included studies are often modeled towards predictive, preventative, personalized, and practical approaches to treatment of disease. The goal of research methodologies in this section is to improve overall patient care and prognosis.
 JoVE Clinical and Translational Medicine

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

1Department of Medicine, Renal division, University of Pittsburgh School of Medicine, 2Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine


JoVE 51807

This manuscript presents a simple, yet powerful, in vitro method for evaluating smooth muscle contractility in response to pharmacological agents or nerve stimulation. Main applications are drug screening and understanding tissue physiology, pharmacology, and pathology.

 JoVE Clinical and Translational Medicine

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

1Multi Organ Transplant Program, Toronto General Hospital, 2Department of Surgery, Toronto General Hospital, 3Department of Medicine, Toronto General Hospital


JoVE 51419

Marginal grafts, such as fatty livers, grafts from older donors, or livers retrieved after cardiac death (DCD) tolerate conventional, cold static storage only poorly. We developed a novel model of subnormothermic ex vivo liver perfusion for preservation, assessment, and repair of marginal liver grafts prior to transplantation.

 JoVE Clinical and Translational Medicine

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

1Department of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, University of Pennsylvania


JoVE 51653

These studies report on reversible attachment of adenoviral gene vectors to coatless metal surfaces of stents and model mesh disks. Sustained release of transduction-competent viral particles contingent upon hydrolysis of cross-linkers used for vector immobilization results in a durable site-specific transgene expression in vascular cells and in stented arteries.

 JoVE Clinical and Translational Medicine

Controlled Cortical Impact Model for Traumatic Brain Injury

1Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research Institute, Department of Neurological Surgery, Indiana University School of Medicine


JoVE 51781

Traumatic brain injuries (TBIs) remain a serious health problem. Using the controlled cortical impact surgery model, research on the effects of TBI and possible treatment methods may be performed.

 JoVE Clinical and Translational Medicine

Ultrasound-guided Transthoracic Intramyocardial Injection in Mice

1Department of Cardiology, Boston Children's Hospital, 2Harvard Stem Cell Institute, Harvard University


JoVE 51566

Echocardiography-guided percutaneous intramyocardial injection represents an efficient, reliable, and targetable modality for the delivery of gene transfer agents or cells into the murine heart. Following the steps outlined in this protocol, the operator can quickly become competent in this versatile, minimally invasive technique.

 JoVE Clinical and Translational Medicine

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

1Department of Neurology, Baylor College of Medicine, 2Neurology Care Line, Michael E. DeBakey VA Medical Center, 3Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 4Department of Neurology, University of California, Los Angeles


JoVE 51442

The Default Mode Network (DMN) in Temporal Lobe Epilepsy (TLE) is analyzed in the resting state of the brain using seed-based functional connectivity MRI (fcMRI).

 JoVE Clinical and Translational Medicine

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

1Institute for Stroke and Dementia Research, University Hospital Munich, 2Munich Cluster for Systems Neurology (SyNergy), 3Department of Neurology, University Heidelberg, 4Imperial College, Charing Cross Hospital


JoVE 51729

Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.

 JoVE Clinical and Translational Medicine

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

1Tissue Engineering Program and Surgical Research, Nationwide Children's Hospital, 2Cardiothoracic Surgery, Nationwide Children's Hospital, 3Pediatric Surgery, Nationwide Children's Hospital


JoVE 51695

In order to understand the cellular and molecular mechanisms underlying neotissue formation and stenosis development in tissue engineered heart valves, a murine model of heterotopic heart valve transplantation was developed. A pulmonary heart valve was transplanted to recipient using the heterotopic heart transplantation technique.

 JoVE Clinical and Translational Medicine

Shrinkage of Dental Composite in Simulated Cavity Measured with Digital Image Correlation

1Minnesota Dental Research Center for Biomaterials and Biomechanics, School of Dentistry, University of Minnesota


JoVE 51191

In order to understand the spatial development of polymerization shrinkage stress in dental resin-composite restorations, Digital Image Correlation was used to provide full-field displacement/strain measurement of restored model glass cavities by correlating images of the restoration taken before and after polymerization.

 JoVE Clinical and Translational Medicine

Primary Culture of Human Vestibular Schwannomas

1Department of Otolaryngology–Head and Neck, University of Iowa Hospitals and Clinics


JoVE 51093

Vestibular Schwannomas (VSs) are non-malignant tumors of Schwann cell (SC) origin, associated with mutations in the NF2 tumor suppressor gene. We report a reproducible, efficient protocol for primary human VS cell culture that allows for molecular and cellular experimental manipulation and analysis and recapitulates the heterogeneous nature of human disease.

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