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Journal / Biochemistry / Fingeraftryk af cardiolipin i leukocytter ved…
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Biochemistry

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JoVE Journal Biochemistry
Fingeraftryk af cardiolipin i leukocytter ved massespektrometri til hurtig diagnose af Barth syndrom
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Fingeraftryk af cardiolipin i leukocytter ved massespektrometri til hurtig diagnose af Barth syndrom

Article DOI: 10.3791/63552-v • 06:48 min • March 23rd, 2022
March 23rd, 2022 •
*1, *2, 2, 2
1Medical School, Swansea University, 2Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro
* These authors contributed equally

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Denne protokol viser, hvordan man opnår et massespektrometrisk "fingeraftryk" af leukocyt cardiolipin til diagnosticering af Barth syndrom. Vurderingen af forhøjet monolysocardiolipin til cardiolipin-forhold diskriminerer patienter med Barth syndrom fra patienter med kontrol hjertesvigt med 100% følsomhed og specificitet.

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