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Journal / Biochemistry / Fingerprinting von Cardiolipin in Leukozyten…
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Biochemistry

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JoVE Journal Biochemistry
Fingerprinting von Cardiolipin in Leukozyten mittels Massenspektrometrie zur schnellen Diagnose des Barth-Syndroms
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Fingerprinting von Cardiolipin in Leukozyten mittels Massenspektrometrie zur schnellen Diagnose des Barth-Syndroms

Article DOI: 10.3791/63552-v • 06:48 min • March 23rd, 2022
March 23rd, 2022 •
*1, *2, 2, 2
1Medical School, Swansea University, 2Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro
* These authors contributed equally

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Dieses Protokoll zeigt, wie man einen massenspektrometrischen "Fingerabdruck" von Leukozyten-Cardiolipin für die Diagnose des Barth-Syndroms erhält. Die Beurteilung des erhöhten Monolysocardiolipin-zu-Cardiolipin-Verhältnisses unterscheidet Patienten mit Barth-Syndrom von Patienten mit kontrollierter Herzinsuffizienz mit 100% Sensitivität und Spezifität.

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Biochemie Ausgabe 181
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