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JoVE Journal Cancer Research
Etablering af zebrafisk patientafledte xenotransplantater fra kræft i bugspytkirtlen til kemosensitivitetstest
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Etablering af zebrafisk patientafledte xenotransplantater fra kræft i bugspytkirtlen til kemosensitivitetstest

Article DOI: 10.3791/63744-v • 06:59 min • May 12th, 2023
May 12th, 2023 •
1, 2, 1, 2, 1
1Department of Biology, University of Pisa, 2General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa

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Prækliniske modeller sigter mod at fremme viden om kræftbiologi og forudsige behandlingseffektivitet. Dette papir beskriver dannelsen af zebrafiskbaserede patientafledte xenotransplantater (zPDX'er) med tumorvævsfragmenter. zPDX'erne blev behandlet med kemoterapi, hvis terapeutiske virkning blev vurderet med hensyn til celleapoptose i det transplanterede væv.

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Kræftforskning udgave 195 zebrafiskavatar præklinisk model co-klinisk forsøg tumortransplantation kemosensitivitet helmonteret immunfluorescens
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