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Cancer Research

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JoVE Journal Cancer Research
Etablering av zebrafisk patient-derived xenografts från bukspottskörtelcancer för kemosensitivitetstestning
Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
Journal (Cancer Research)
Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
Journal (Cancer Research)
Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
 
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Etablering av zebrafisk patient-derived xenografts från bukspottskörtelcancer för kemosensitivitetstestning

Article DOI: 10.3791/63744-v • 06:59 min • May 12th, 2023
May 12th, 2023 •
1, 2, 1, 2, 1
1Department of Biology, University of Pisa, 2General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa

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Prekliniska modeller syftar till att öka kunskapen om cancerbiologi och förutsäga behandlingseffekt. Denna artikel beskriver genereringen av zebrafiskbaserade patient-derived xenografts (zPDX) med tumörvävnadsfragment. ZPDX behandlades med kemoterapi, vars terapeutiska effekt bedömdes med avseende på cellapoptos av den transplanterade vävnaden.

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Cancerforskning utgåva 195 zebrafiskavatar preklinisk modell samklinisk prövning tumörtransplantation kemosensitivitet helmonterad immunofluorescens
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