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JoVE Journal Cancer Research
Etablering av sebrafisk pasientderiverte xenotransplantater fra bukspyttkjertelkreft for kjemosensitivitetstesting
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Etablering av sebrafisk pasientderiverte xenotransplantater fra bukspyttkjertelkreft for kjemosensitivitetstesting

Article DOI: 10.3791/63744-v • 06:59 min • May 12th, 2023
May 12th, 2023 •
1, 2, 1, 2, 1
1Department of Biology, University of Pisa, 2General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa

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Prekliniske modeller tar sikte på å fremme kunnskapen om kreftbiologi og forutsi behandlingseffekt. Denne artikkelen beskriver genereringen av sebrafiskbaserte pasientderiverte xenotransplantater (zPDX) med tumorvevsfragmenter. ZPDX-ene ble behandlet med kjemoterapi, hvis terapeutiske effekt ble vurdert med hensyn til celleapoptose i det transplanterte vevet.

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Cancer Research sebrafisk avatar preklinisk modell co-klinisk studie tumortransplantasjon kjemosensitivitet hel-mount immunfluorescens
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