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A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
DOI:

07:33 min

May 21, 2010

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Chapters

  • 00:00Title
  • 01:22Introduction
  • 01:58Ledge Test
  • 03:25Hindlimb Clasping
  • 04:19Gait Test
  • 06:17Representative Assessment Results
  • 06:52Conclusion

Summary

Automatic Translation

We describe a protocol for the rapid and sensitive quantification of disease severity in mouse models of cerebellar ataxia. Measures include hind limb clasping, ledge test, gait and kyphosis. This protocol effectively discriminates between affected and non-affected individuals, and detects the progression of affected individuals over time.

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