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Neuroscience

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A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
 

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

Article doi: 10.3791/1787
May 21st, 2010

Summary May 21st, 2010

We describe a protocol for the rapid and sensitive quantification of disease severity in mouse models of cerebellar ataxia. Measures include hind limb clasping, ledge test, gait and kyphosis. This protocol effectively discriminates between affected and non-affected individuals, and detects the progression of affected individuals over time.

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