Mr Thermometry
Mr Thermometry - Related Videos
11:27
Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
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Cited by 5 •
2016
This protocol describes the preparation and characterization of a dendrimeric magnetic resonance imaging (MRI) contrast agent that carries cyclen-based macrocyclic chelates coordinating paramagnetic gadolinium ions. In a series of MRI experiments in vitro, this agent produced an amplified MRI signal when compared to the commercially available monomeric analogue.
06:33
Method for Simultaneous fMRI/EEG Data Collection during a Focused Attention Suggestion for Differential Thermal Sensation
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Cited by 4 •
2014
We present a protocol for concurrent collection of EEG/fMRI data, and synchronized MR clock signal recording. We demonstrate this method using a unique paradigm whereby subjects receive ‘cold glove’ instructions during scanning, and EEG/fMRI data are recorded along with hand temperature measurements both before and after hypnotic induction.
09:21
Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
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Cited by 22 •
2015
The method presented here uses 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET-CT) and fat-water separated magnetic resonance imaging (MRI), each scanned following 2 hr exposure to thermoneutral (24 °C) and cold conditions (17 °C) in order to map brown adipose tissue (BAT) in adult human subjects.
13:04
Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
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Cited by 13 •
2019
Cultured primary or established cell lines are commonly used to address fundamental biological and mechanistic questions as an initial approach before using animal models. This protocol describes how to prepare whole cell extracts and subcellular fractions for studies of zinc (Zn) and other trace elements with atomic absorbance spectroscopy.
07:47
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
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Cited by 17 •
2015
AN MRI-compatible custom-designed laser-based heating apparatus has been developed to provide local heating of subcutaneous tumors in order to activate release of agents from thermosensitive liposomes specifically at the tumor region.
FAQs
The key signal is the proton resonance frequency, which changes as tissue temperature changes. That shift alters the phase of the MR signal, allowing temperature-related differences to be detected in phase images. The resulting measurements provide spatial information about where heating occurs, rather than only indicating an overall temperature change across the imaged tissue.
A baseline phase image provides the reference needed to identify temperature-related signal changes during treatment. Comparing subsequent phase images with that initial state helps distinguish evolving thermal effects from the tissue’s original signal pattern. This comparison supports spatial temperature estimation and allows treatment teams to observe how heating develops over time.
Three-dimensional feedback shows the distribution of temperature changes throughout the treated region and nearby tissue. This spatial view helps reveal whether energy is reaching the intended target and whether heating extends beyond it. In bioengineering, such information supports more precise treatment planning and improves assessment of how safely a thermal intervention is being delivered.
A typical workflow begins by acquiring baseline phase images before energy delivery. MR images are then collected during treatment, and their phase information is compared with the baseline to estimate temperature changes across the tissue. The resulting maps provide ongoing feedback about heating, helping guide energy delivery and evaluate effects on surrounding regions.
MR thermometry can monitor heating produced by focused ultrasound, radiofrequency, and laser-based thermal therapies. During these interventions, temperature maps show how the delivered energy changes tissue temperature in space and over time. This information helps guide the treatment toward its intended target while supporting efforts to limit thermal effects in surrounding tissue.
In bioengineering, MR thermometry supplies real-time, three-dimensional feedback for developing image-guided therapeutic technologies. Researchers can use the temperature information to refine treatment planning, assess safety, and study how energy delivery affects biological tissues. Its noninvasive monitoring capability connects imaging, thermal control, and therapeutic device development within a single treatment-support framework.