3d Heart Model

A 3D heart model is a physical, digital, or tissue-based representation of the heart that preserves its three-dimensional anatomy and supports the study of cardiac structure and function. By organizing chambers, valves, muscle layers, and major blood vessels in spatial relationships, these models can illustrate how electrical activity, muscle contraction, and blood flow coordinate the cardiac cycle. In biology, 3D heart models help students visualize anatomy and enable researchers to investigate development, congenital abnormalities, cardiovascular disease, and treatment strategies. More advanced models can also support patient-specific planning, cardiac tissue engineering, and testing of medical devices.

3d Heart Model - Related Videos

Research

JoVE Journal - Medicine

3D Whole-heart Myocardial Tissue Analysis

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Cited by 2 •

2017

This protocol describes a novel method for the 3D comparison of whole-heart myocardial tissue with MRI. This is designed for the accurate assessment of intramyocardial injections in the infarct border zone of a chronic porcine model of myocardial infarction.

The Inverted Heart Model for Interstitial Transudate Collection from the Isolated Rat Heart

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2017

This protocol describes a method to collect cardiac interstitial fluid from the isolated, perfused rat heart. To physically separate interstitial transudate from coronary venous effluent perfusate, the Langendorff perfused heart is inverted, and the transudate (interstitial fluid) formed on the cardiac surface is collected using a soft latex cap.

Research

JoVE Journal - Medicine
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An Isolated Working Heart System for Large Animal Models

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Cited by 22 •

2014

Most studies involving the Langendorff apparatus use small animal models due to the increased complexity of systems for larger mammals. We describe a Langendorff system for large animal models that allows for use across a range of species, including humans, and relatively easy data acquisition.

Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration

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Cited by 12 •

2016

A step-by-step video protocol of apical resection is demonstrated in this study. Apical resection is a recently highlighted surgical approach in mammalian heart regeneration research. This study may promote the application of apical resection as a standard methodology in research into the mechanism underlying heart regeneration.

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

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Cited by 14 •

2013

A methodology to estimate ventricular fiber orientations from in vivo images of patient heart geometries for personalized modeling is described. Validation of the methodology performed using normal and failing canine hearts demonstrate that that there are no significant differences between estimated and acquired fiber orientations at a clinically observable level.

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