Cecum
Cecum - Related Videos
04:08
Intracecal Tumor Cell Injection: A Technique to Deliver Cancer Cells for Establishing Orthotopic Colorectal Cancer Mouse Model
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2023
The video describes the technique for intracecal injection of cancerous cells to develop an orthotopic mouse model with highly uniform tumors. Therefore, the orthotopic mouse model allows realistic simulation of metastasis, providing a valuable tool to study the phenotype changes during tumor growth and dissemination.
06:19
Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer
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Cited by 13 •
2017
We describe the establishment of orthotopic colorectal tumors via injection of tumor cells or organoids into the cecum of mice and the subsequent isolation of circulating tumor cells (CTCs) from this model.
10:05
Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut
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Cited by 34 •
2011
Trichuris muris infection is an intestinal model of Th2 immunity where resistant mice generate a protective Th2 response and susceptible mice generate a pathological Th1 response.
06:44
Creation of Abdominal Adhesions in Mice
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Cited by 9 •
2016
Abdominal adhesions that form after surgery are a major cause of pain, infertility, and hospitalization and reoperation for small bowel obstruction. Our surgical procedure for creating abdominal adhesions in mice is a reliable tool to study the mechanisms underlying the formation of adhesions.
11:53
Cecal Ligation Puncture Procedure
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Cited by 200 •
2011
The mouse model of cecal ligation and puncture as a valuable tool for the study of human sepsis.
FAQs
The ileocecal valve regulates how intestinal contents leave the ileum and enter the cecum, helping control the timing and direction of digestive flow. This regulation gives the cecum an opportunity to retain material temporarily rather than allowing unrestricted passage into the colon. Its activity therefore connects small-intestinal transport with downstream processing.
Temporary retention keeps intestinal material in contact with resident microbes for a period of time, supporting microbial activity within the cecum. The biological importance of that activity depends on the animal’s digestive strategy: microbial processing contributes more substantially to plant-fiber use in many herbivores than it does in humans.
Cecal function reflects dietary adaptation. In many herbivores, resident microbes in the cecum ferment plant fiber, making this chamber important for processing a fiber-rich diet. Humans have a more limited cecal role, so comparing these organisms helps biologists relate gastrointestinal structure and microbial activity to differences in nutrient processing.
Comparing the cecum across organisms can show how gastrointestinal anatomy corresponds to diet and nutrient-processing demands. A cecum that supports substantial microbial fermentation has a different functional significance from the more limited human cecum. Such comparisons help biology link anatomical variation with digestive strategies rather than treating the chamber as identical across species.
The cecum provides anatomical context for examining disorders involving the appendix or intestinal inflammation because these conditions occur in or near a junction connecting major intestinal regions. Studying this area helps researchers relate local anatomy to digestive flow and microbial activity, while also clarifying how disease can affect gastrointestinal organization and function.
The cecum offers a setting for examining how resident microbes interact with the gastrointestinal environment and contribute to nutrient processing. This is especially informative in animals that depend on microbial fermentation of plant fiber. In biology, cecal research therefore connects anatomy with microbial activity, dietary adaptation, and the relationship between host tissues and resident organisms.