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Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut
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Immunology and Infection
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JoVE Journal Immunology and Infection
Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

DOI:
10.3791/2774-v

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10:05 min

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May 24, 2011

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, , ,
1The Biomedical Research Centre,University of British Columbia, 2Department of Pathology and Laboratory Medicine,University of British Columbia

Chapters

  • 00:05Title
  • 01:37Propagation of Trichuris muris Eggs
  • 04:58Acute Infection of Experimental Mice with Trichuris muris Eggs
  • 07:52Enumeration of Trichuris muris Worms in the Cecum
  • 08:48Analysis of Trichuris muris Infection and Host Responses in Resistant B6 or Susceptible AKR Mice
  • 09:42Conclusion

Summary

Automatic Translation

Automatic Translation

Trichuris muris infection is an intestinal model of Th2 immunity where resistant mice generate a protective Th2 response and susceptible mice generate a pathological Th1 response.

Tags

Trichuris Muris InfectionType 2 ImmunityInflammation In The GutIntestinal Epithelial CellsCD4+ T Helper Cell ActivationResistant Inbred StrainsTh2 Polarized CytokinesTh1-associated CytokinesIntestinal Microenvironment ChangesWorm ExpulsionTrichuris Muris EggsExperimental HarvestPost-infection Analysis

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