Epileptic Spasms

Epileptic spasms are brief, age-dependent seizures marked by sudden flexion, extension, or mixed movements of the trunk and limbs, most often beginning during infancy. They result from abnormal, synchronized electrical activity in the brain and commonly occur in clusters, sometimes around waking, with electroencephalography helping identify characteristic seizure patterns. Recognizing these events promptly is important because untreated spasms can interfere with brain development and may be associated with developmental regression. In biology and neuroscience, studying epileptic spasms supports research into early-life brain circuits, seizure mechanisms, diagnostic monitoring, and therapies aimed at improving long-term neurological outcomes.

Epileptic Spasms - Related Videos

Education

JoVE Core - Anatomy and Physiology

Vascular Spasm

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2025

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...

Research

JoVE EoE - Neurophysiology

Electroencephalographic Recording of Epileptic Seizures in Epilepsy-Induced Rats

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2025

This video demonstrates electroencephalographic (EEG) recording of epileptic seizures in epilepsy-induced rats. A rat with electrodes implanted in the ventral hippocampus is connected to the EEG recording system and placed in a plexiglass chamber. The rat is allowed to move freely while the brain activity is recorded to monitor the occurrence of seizures.

Electrophoretic Delivery of GABA into the Epileptic Focus of an Anesthetized Mouse

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2025

Source: Slezia, A. et al. Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice. J. Vis. Exp. (2019)This video demonstrates the electrophoretic delivery of gamma-aminobutyric acid (GABA) to inhibit seizure activity in an anesthetized mouse. It outlines the steps involved in probe implantation, neural activity recording, seizure induction, and controlled GABA delivery via a microfluidic ion pump to assess its therapeutic efficacy.

Impact of Direct Current Stimulation on Evoked Epileptic Seizures in Mouse Brain Slices

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2025

The video demonstrates a study for assessing the impact of direct current stimulation (DCS) on epileptic seizures in mouse brain slices. The brain slices containing the connected medial thalamus (MT) and anterior cingulate cortex (ACC) regions are placed in a multielectrode array (MEA). Electrical stimuli to the MT and seizure-inducing drugs are applied to induce epileptic seizures in the ACC. DCS is then applied to assess its impact on evoked seizures.

Measurement of Myocardial Lactate Production for Diagnosis of Coronary Microvascular Spasm

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Cited by 15 •

2021

Myocardial lactate production (coronary arterial-venous difference in serum lactate level) during coronary spasm provocation testing is considered as a highly sensitive marker that reflects acetylcholine-induced myocardial ischemia due to microvascular spasm. This article presents the procedures to assess myocardial lactate production for the diagnosis of coronary microvascular spasm.

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