Intracranial Hypertension
Intracranial Hypertension - Related Videos
08:27
Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.
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Cited by 13 •
2015
We describe a method for creating a reliable model of cerebral venous hypertension in the adult mouse. This model has been widely described and tested in the rat. This new counterpart in the mice opens the possibility of using genetic modified animals and thereby broadens the applications of the model.
01:55
Intracranial Injection of Gut-Derived Microbial Metabolites in a Mouse Model
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2025
Source: Liou, C. et al. Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice. J. Vis. Exp. (2022).This video demonstrates the intracranial injection of short-chain fatty acids (SCFAs) in a freely moving mouse to study their effects on brain-mediated behavior. An injector cannula is inserted into a guide cannula implanted in the mouse brain. After recovery, the mouse acclimates in a novel cage. SCFAs are then administered, and locomotor behavior is recorded.
09:04
Epidural Intracranial Pressure Measurement in Rats Using a Fiber-optic Pressure Transducer
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Cited by 30 •
2012
A novel technique to record the pressures within the skull is described. The minimally invasive method uses a fibre-optic pressure sensing system to accurately measure intracranial pressure (ICP) in anaesthetized rats without causing significant brain trauma. The technique may be used in a wide range of experimental models.
02:25
Synergistic Effect of Intracranial and Intraperitoneal Delivery of Analgesic Drugs on Thermal Pain Response in a Rat
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2025
Source: Martinez, E., et al. Intracranial Pharmacotherapy and Pain Assays in Rodents. J. Vis. Exp. (2019).This video demonstrates the intracranial administration of an analgesic drug in an anesthetized rat with a pre-implanted guide cannula in the prefrontal cortex. An additional analgesic drug is co-administered intraperitoneally. Following recovery, the rat’s thermal pain response is assessed using Hargreave’s apparatus, where paw withdrawal latency is measured to evaluate the analgesic...
08:47
Intracranial Injection of Adeno-associated Viral Vectors
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Cited by 56 •
2010
Here we present the intracranial injection of AAV vectors for fluorescent labeling of neurons and glia in the visual cortex.
FAQs
The key consequence is that rising intracranial pressure can reduce cerebral perfusion, meaning less blood flow is available to support brain tissue. This links the physical limits of the skull to neurological health. Studying that relationship helps explain why pressure changes can progress from an internal imbalance to impaired brain function.
Traumatic injury, bleeding, tumors, infection, and disrupted cerebrospinal fluid flow represent different initiating problems that can disturb the contents or circulation within the skull. Although their origins differ, each may contribute to sustained pressure elevation and neurological risk. Comparing these causes helps biology identify how varied disturbances affect a shared intracranial environment.
Brain homeostasis depends on maintaining a workable balance among brain tissue, blood, and cerebrospinal fluid inside the skull. Pressure becomes biologically important when that balance can no longer compensate for a change in one component. Investigating intracranial hypertension therefore provides a way to study how the brain responds when its internal physical conditions become unstable.
Monitoring pressure can help reveal when the intracranial environment is becoming more hazardous to brain function. In clinical and biological investigations, that information supports recognition of neurological deterioration and helps connect pressure changes with reduced cerebral perfusion. It also provides a basis for developing strategies intended to limit additional damage after the initial disturbance.
A useful investigation should consider the skull as a rigid compartment and examine how brain tissue, blood, and cerebrospinal fluid contribute to pressure balance. It should also relate pressure elevation to cerebral perfusion and neurological health. This approach keeps both the physical mechanism and its biological consequences in view rather than treating pressure as an isolated measurement.
The condition is relevant because pressure elevation can follow several harmful events, including injury, bleeding, tumors, infection, or altered cerebrospinal fluid flow. Research can use this shared consequence to study neurological deterioration after those events and to develop approaches for monitoring pressure and limiting secondary brain damage. Its importance therefore extends across multiple areas of brain biology.