Inulin Maltodextrin
Inulin Maltodextrin - Related Videos
07:07
A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
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Cited by 65 •
2013
Measurement of glomerular filtration rate (GFR) is the gold standard for kidney function assessment. Here we describe a high-throughput method which allows the determination of GFR in conscious mice by using a single bolus injection, determination of fluorescein isothiocyanate (FITC)-inulin in plasma and calculation of GFR by a two-phase exponential decay model.
09:58
A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
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Cited by 45 •
2016
The epithelial cells of the choroid plexus (CP) form the blood-cerebrospinal fluid barrier (BCSFB). An in vitro model of the BCSFB employs human choroid plexus papilloma (HIBCPP) cells. This article describes culturing and basolateral infection of HIBCPP cells using a cell culture filter insert system.
07:54
Use of a Hanging-weight System for Isolated Renal Artery Occlusion
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Cited by 6 •
2011
A precise murine model for acute kidney injury (AKI) due to ischemia is an important tool to investigate acute kidney injury and possibly find therapeutic tools to treat renal injury. The hanging weight system offers a tool for immediate and reliable renal artery occlusion and reperfusion without causing renal congestion.
03:37
Intranasal Drug Administration in Mice via Pipette and Reverse-Cannulation for Nose-to-Brain Drug Delivery
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2025
Source: Kanazawa, T., et al. Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery. J. Vis. Exp. (2018)This video demonstrates the intranasal administration of radiolabeled drugs in an anesthetized mouse to achieve nose-to-brain drug delivery. It explains how drugs cross the nasal epithelium and travel via neuronal pathways to reach the brain, as well as how ciliary motion influences drug retention and clearance. Additionally, the video...
08:50
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Cited by 30 •
2013
A two-stage method to establish chronic kidney disease (CKD) in the Lewis rat by surgically removing 5/6th of renal mass is described. Combination of the surgical procedure, NOS-inhibition and a high-salt diet leads to a model resembling human CKD, allowing study of causal mechanisms and development of novel therapeutic interventions.
FAQs
The formulation can create two different carbohydrate streams: maltodextrin supplies glucose after relatively accessible hydrolysis, while inulin remains available for microbial metabolism rather than immediate host digestion. This contrast lets researchers examine how rapidly available carbohydrate and fermentable fiber coexist, helping separate effects associated with energy delivery from those associated with intestinal microbial activity.
Microbial fermentation provides a biological route for using the inulin fraction that human digestive enzymes largely leave intact. Its conversion into short-chain fatty acids connects the carbohydrate formulation with gut microbial metabolism and potential host-microbe interactions. Consequently, studies can evaluate not only whether carbohydrate disappears, but also how microbial processing changes the intestinal environment.
Changing the formulation balance can alter the relative contribution of rapid glucose availability and microbial fermentation. A preparation emphasizing maltodextrin may highlight readily accessible carbohydrate, whereas greater inulin representation may emphasize fermentation-related responses. This distinction matters when interpreting biological results, because measured effects can reflect both substrate delivery to the host and substrate availability to gut microorganisms.
Researchers can use the formulation to investigate how a digestible carbohydrate component and a fermentable fiber component influence gut microbial activity within the same experimental context. Observations may address fermentation, short-chain fatty acid production, and host-microbe relationships. The combined design is useful when the research question concerns interactions between nutrient handling and microbial ecology rather than either process alone.
Its contrasting nutritional properties support studies of prebiotic effects, energy delivery, and carbohydrate handling. Investigators may compare biological responses associated with rapidly available glucose-related substrate against responses associated with microbial fermentation of fiber. This makes the formulation relevant to experimental diets and food research where both immediate nutrient supply and longer microbial processing are important outcomes.
Combining the two carbohydrate types allows formulation design to consider more than total carbohydrate content. The resulting system can be evaluated according to how much substrate is positioned for rapid hydrolysis versus microbial fermentation. In food or experimental-diet research, that distinction helps align carbohydrate composition with the intended biological question, such as energy supply, prebiotic activity, or gut ecology.