Lab-on-a-chip
Lab-on-a-chip - Related Videos
04:14
Lab Techniques - Concepts
0 Views •
2020
Measurement Accuracy The ability to repeat an experiment and get the same results, or reproducibility, is essential in scientific research. However, it’s impossible to repeat an experiment if you don’t know how you did it. Thus, scientists keep detailed records of their experiments in lab notebooks. These records include important information like the amount of each material used and descriptions of each step of the procedure. Equipment, like balances and volumetric or graduated glassware, is...
01:21
Lab Techniques - Instructor Prep
0 Views •
2020
Source: Smaa Koraym at Johns Hopkins University, MD, USA Preparation of LaboratoryExpand Here we show the laboratory preparation for 10 students working individually, with some excess. Please adjust quantities as needed. To set up for this lab experiment, wear the appropriate personal protective equipment, including a lab coat, chemical splash goggles, and gloves. Obtain enough small plastic bottles with caps for the number of students and label them ‘NaCl’. Use a...
08:53
Lab Techniques - Student Protocol
0 Views •
2020
Source: Smaa Koraym at Johns Hopkins University, MD, USA Determining the Density of an EggExpand Density is a measure of how compact a substance or object is, and it is calculated as mass divided by volume. When a dense object is placed in a liquid with a lower density, the object sinks; when the object is less dense than the liquid, it floats. When the densities are the same, the object will be suspended in the liquid. In this experiment, we'll determine the density of an egg by creating a...
11:23
Lensless Fluorescent Microscopy on a Chip
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Cited by 8 •
2011
A lensless on-chip fluorescent microscopy platform is demonstrated that can image fluorescent objects over an ultra-wide field-of-view of e.g., >0.6-8 cm2 with <4μm resolution using a compressive sampling based decoding algorithm. Such a compact and wide-field fluorescent on-chip imaging modality could be valuable for high-throughput cytometry, rare-cell research and microarray-analysis.
07:32
Dynamic Electrochemical Measurement of Chloride Ions
0 Views •
Cited by 5 •
2016
Dynamic measurement of chloride ions is presented. Transition time of an Ag/AgCl electrode, during a chronopotentiometric technique, can give the concentration of chloride ions in electrolyte. This method does not require a stable conventional reference electrode.
FAQs
Microfluidic channels determine how a sample moves through the device by directing fluid along microscale pathways. Their structures can support sequential operations such as mixing, separation, and reaction, allowing several laboratory functions to occur within a controlled route. This channel-level organization links fluid handling to biological analysis rather than merely miniaturizing a container.
Flow can be controlled by pumps, valves, or capillary forces, and each provides a way to move biological fluids through the channel network. Pumps and valves support deliberate control of movement, while capillary forces can drive fluid transport within the microscale structure. These mechanisms determine how samples reach mixing, separation, reaction, or detection regions.
Working with small fluid volumes reduces reagent use and can shorten processing time, which is especially relevant when biological assays require multiple operations. On a compact platform, sample preparation, analysis, and detection can be combined instead of treated as entirely separate stages. The result is an integrated workflow that supports rapid biological testing while conserving materials.
A typical workflow begins by introducing a biological sample, then directing it through microscale operations such as preparation, mixing, separation, or reaction. The processed material proceeds to an analysis and detection stage on the same platform. This sequence allows a device to connect handling and measurement in one workflow, rather than requiring each operation to occur on separate equipment.
Researchers apply these platforms to rapid diagnostics, cell analysis, genetic testing, and investigations of biomolecular interactions. The appropriate use depends on the biological question: cells may be examined directly, genetic testing may be performed, or molecular interactions may be studied. Because the compact approach supports different operations, these systems serve both research and clinical settings.
In biology, the main practical gains are portability, automation, reduced reagent consumption, and shorter processing time. These features can support access to biological analysis in research and clinical settings, including situations where compact testing is useful. The technology therefore connects microscale fluid control with broader goals of making biological workflows more rapid, portable, and integrated.