Microvilli

Microvilli are microscopic, fingerlike projections of a cell’s plasma membrane that increase surface area for exchange with the surrounding environment. Each microvillus contains a tightly bundled core of actin filaments anchored to the cell cortex, while membrane proteins and enzymes support transport, digestion, or sensing at its surface. In biology, microvilli are especially prominent on intestinal epithelial cells, where dense brush borders expand the absorptive interface for nutrients and fluids, and on kidney tubule cells, where they support reabsorption. Their structure illustrates how cellular architecture can optimize membrane-based processes and tissue function.

Microvilli - Related Videos

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JoVE Core - Anatomy and Physiology

Microvilli

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2023

Microvilli are tiny finger-like projections found on the surface of certain cells. Their purpose is to increase the surface area of the cell's apical surface, resulting in more effective absorption or secretion of substances. These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity to...

Research

JoVE EoE - Neuroimaging

Visualization of a Mouse Brain Choroid Plexus Using Scanning Electron Microscopy

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2025

Source: Van Wonterghem, E., et al. Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus. J. Vis. Exp. (2022)This video demonstrates the preparation and imaging of choroid plexus tissue from a mouse brain using scanning electron microscopy (SEM). The process includes tissue fixation, dehydration, and coating with a conductive platinum layer to stabilize and prepare the sample for imaging. SEM captures detailed images of epithelial cells with...

Research

JoVE Journal - Neuroscience
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Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation

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Cited by 15 •

2011

In mice, the ability to detect pheromones is principally mediated by the vomeronasal organ (VNO). Here, an acute tissue slice preparation of VNO for performing calcium imaging is described. This physiological approach allows observations of subpopulations and/or individual neurons in a living tissue and is convenient for receptor-ligand identification.

An Immunofluorescence-Based Method for Visualizing Tuft Cells in Jejunum Cryosections

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2025

This video illustrates an immunofluorescence-based method for visualizing intestinal tuft cells in free-floating mouse jejunum cryosections. Within the intestinal villi, the co-localization of green fluorescence at the luminal tip with an extended red rootlet mass indicates the presence of tuft cells.

Studying Membrane Protein Trafficking in Drosophila Photoreceptor Cells

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2025

Source: Wagner, K. et al., Studying Membrane Protein Trafficking in Drosophila Photoreceptor Cells Using eGFP-Tagged Proteins. J. Vis. Exp. (2022).This video demonstrates the visualization of membrane protein trafficking in Drosophila photoreceptor cells using eGFP-tagged TRPL proteins. It details the preparation of transgenic flies for imaging, the capture of fluorescence images of photoreceptor cells, and the quantification of TRPL trafficking by measuring relative eGFP fluorescence in the...

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