Molecular Biology
Molecular Biology - Related Videos
09:27
An Introduction to Molecular Developmental Biology
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2023
Molecular signals play a major role in the complex processes occurring during embryonic development. These signals regulate activities such as cell differentiation and migration, which contribute to the formation of specific cell types and structures. The use of molecular approaches allows researchers to investigate these physical and chemical mechanisms in detail. This video will review a brief history of the study of molecular events during development. Next, key questions asked by molecular...
12:50
Using Whole Mount in situ Hybridization to Link Molecular and Organismal Biology
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Cited by 13 •
2011
Whole mount in situ hybridization (WISH) was used in an upper level undergraduate Comparative Vertebrate Biology course in addition to vertebrate dissections. This gave students the opportunity to study gene expression patterns as well as gross anatomy, linking the study of molecular and organismal biology within one course.
11:20
Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
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Cited by 14 •
2018
Automated systems and protocols for the routine preparation of a large number of screens and nanoliter crystallization droplets for vapor diffusion experiments are described and discussed.
09:22
Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry
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Cited by 29 •
2010
Laser ablation electrospray ionization (LAESI) is an atmospheric-pressure ion source for mass spectrometry. In the imaging mode, a mid-infrared laser probes the distributions of molecules across a tissue section or a biofilm. This technique presents a new approach for diverse bioanalytical studies carried out under native experimental conditions.
12:02
Molecular Evolution of the Tre Recombinase
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Cited by 4 •
2008
Here we report the generation of Tre recombinase through directed, molecular evolution. Tre recombinase recognizes a pre-defined target sequence within the LTR sequences of the HIV-1 provirus, resulting in the excision and eradication of the provirus from infected human cells. While still in its infancy, directed molecular evolution will allow the creation of custom enzymes that will serve as tools of molecular surgery and molecular medicine.
FAQs
These processes form a connected information pathway. DNA replication copies genetic information so it can be transmitted, transcription converts that information into RNA, and translation uses the RNA to produce proteins. Because proteins influence cell structure and function, changes at any stage can affect how biological information is expressed and how cells operate.
Gene regulation determines how biological information is used rather than merely whether DNA exists in a cell. By investigating regulation alongside interactions among DNA, RNA, proteins, and other biomolecules, molecular biology helps explain differences in cellular behavior. This focus is especially relevant when researchers examine changes associated with normal function or disease.
Molecular biology can connect mutations with changes in biological information and cellular behavior. Studying these changes helps researchers examine how altered DNA may influence RNA production, protein-related functions, or interactions among biomolecules. This provides a molecular basis for investigating how cellular changes contribute to health and disease, without relying only on visible symptoms.
Within biology, molecular biology supplies a detailed account of how biomolecules carry and use information. That perspective complements the study of cells, organisms, and health by linking molecular events to broader biological outcomes. It is therefore useful for interpreting cellular function, examining disease-related changes, and developing applications based on genetic information.
A molecular biology investigation may examine DNA, RNA, proteins, gene regulation, mutations, or interactions among biomolecules. The selected focus depends on the biological question, such as how information is transmitted, how cellular function is influenced, or how disease-associated changes arise. This scope allows researchers to connect molecular observations with biological outcomes.
It supports diagnostic testing by providing a way to investigate biological information and molecular changes associated with health or disease. Researchers can use knowledge of DNA, RNA, proteins, mutations, and their regulation to examine disease-related processes. The resulting molecular perspective can contribute to identifying or studying conditions as part of broader medical research.
Drug development benefits from understanding the molecular processes that influence cell structure and function. By studying DNA, RNA, proteins, gene regulation, and biomolecular interactions, researchers can investigate how cellular systems operate and how disease-related changes arise. This knowledge supports efforts to develop treatments that address biological processes linked to health and disease.
It provides the molecular knowledge needed to study and work with genetic information, including how DNA is copied, converted into RNA, and used to produce proteins. Understanding these relationships supports biotechnology and genetic engineering by connecting changes in genetic information with potential effects on proteins, cells, and biological function.