Superparamagnetic Iron Oxide
Superparamagnetic Iron Oxide - Related Videos
08:26
Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
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Cited by 20 •
2015
Targeted cell delivery is useful in a variety of biomedical applications. The goal of this protocol is to use superparamagnetic iron oxide nanoparticles (SPION) to label cells and thereby enable magnetic cell targeting approaches for a high degree of control over cell delivery and localization.
09:54
Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
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Cited by 1 •
2020
To improve serological diagnostic tests for Mycobacterium tuberculosis antigens, we developed superparamagnetic iron oxide nanoprobes to detect extrapulmonary tuberculosis.
08:59
Fabrication of a Functionalized Magnetic Bacterial Nanocellulose with Iron Oxide Nanoparticles
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Cited by 42 •
2016
Here, we present a protocol to make a bacterial nanocellulose (BNC) magnetic for applications in damaged blood vessel reconstruction. The BNC was synthesized by G. xylinus strain. On the other hand, magnetization of the BNC was realized through in situ precipitation of Fe2+ and Fe3+ ferrous ions inside the BNC mesh.
01:25
Isolation of Ammonium-Oxidizing Iron Reducers from a Wetland Soil–Derived Enrichment Culture
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2025
Begin with a wetland soil-derived enrichment culture containing bacterial communities.The culture exhibits Feammox activity, ammonium oxidation coupled to ferric iron reduction, indicating the enrichment of a bacterium capable of this metabolic process.Serially dilute the culture using media.Streak the diluted samples onto test agar plates supplemented with ferric iron and ammonium.Use control plates that lack either ferric iron or ammonium, or contain ferric iron with organic carbon instead of...
05:05
Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle
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Cited by 95 •
2011
We describe a technique for labeling and tracking stem cells with FDA-approved, superparamagnetic iron oxide (SPIO), ferumoxytol (Feraheme). This cellular imaging technique that utilizes magnetic resonance (MR) imaging for visualization, is readily accessible for long-term monitoring and diagnosis of successful or unsuccessful stem cell engraftments in patients.
FAQs
At the nanoscale, thermal fluctuations disrupt permanent alignment within the particles’ magnetic domains. An external magnetic field can still align those domains strongly, producing a temporary magnetic response. This balance between field-driven alignment and thermally driven disorder explains why the particles can be magnetically controlled without retaining substantial magnetization after the field is removed.
Reversibility allows researchers to manipulate labeled cells, biomolecules, or other biological materials while the magnetic field is applied and reduce persistent magnetic effects afterward. Because the particles show little or no residual magnetism, they are less likely to remain permanently magnetically aligned, supporting controlled handling and helping avoid persistent magnetic aggregation.
A permanently magnetized particle retains magnetic alignment after an external field is removed, whereas Superparamagnetic Iron Oxide has little or no residual magnetism under those conditions. Its magnetic response therefore depends on the presence of the applied field. This distinction is especially relevant when biological materials must be captured, moved, or released in a controlled manner.
The applied field temporarily aligns the particles’ magnetic domains and makes labeled biological materials responsive to magnetic control. This field-dependent behavior provides the basis for manipulating cells or biomolecules and for influencing where labeled materials are handled. Once the field is removed, the reduced residual magnetism supports a more reversible magnetic process.
They support several biological applications, including magnetic resonance imaging contrast, cell separation, targeted delivery, and tracking of cells or biomolecules. In imaging, they help provide contrast, while in manipulation-oriented applications their magnetic response enables researchers to control labeled materials. These uses connect the particles’ physical behavior with diagnostic and biotechnology workflows.
Cells or biomolecules can be labeled with Superparamagnetic Iron Oxide so that an external magnetic field can influence their handling. The particles thereby provide a magnetic means of controlling or identifying labeled biological material. This capability supports cell separation and tracking studies, while the reversible response helps limit persistent magnetic aggregation after field exposure.