Umbilical Arteries
Umbilical Arteries - Related Videos
08:06
Isolation of Human Umbilical Arterial Smooth Muscle Cells (HUASMC)
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Cited by 8 •
2010
The umbilical cords are used to isolate smooth muscle cells by different ways. In this work we used the enzymatic treatment to isolated smooth muscle cells.
09:19
Isolation of Human Umbilical Vein Endothelial Cells (HUVEC)
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Cited by 129 •
2007
This video protocol illustrates the isolation and culture of human umbilical vein endothelial cells (HUVEC) from human umbilical cord. Once isolated these cells can be used for in vitro angiogenesis assays like the Optimized Fibrin Gel Bead Assay also demonstrated by the Hughes lab.
14:06
Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
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Cited by 2 •
2013
Here we describe a protocol for isolating subsets of precursor B-cells from umbilical cord blood. A sufficient quantity and quality of nucleic acids may be extracted from the cells and used in subsequent assays utilizing DNA or RNA.
08:54
Isolation of Human Umbilical Vein Endothelial Cells and Their Use in the Study of Neutrophil Transmigration Under Flow Conditions
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Cited by 33 •
2012
This article first describes a procedure for isolating human endothelial cells from umbilical veins and then shows how to use these cells to examine neutrophil transmigration under flow conditions. By using a low-volume flow chamber made from a polymer with the optical characteristics of glass, live-cell fluorescent imaging of rare cell populations is also possible.
07:26
Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
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Cited by 16 •
2017
The goal of this protocol is to isolate endothelial progenitor cells from umbilical cord blood. Some of the applications include using these cells as a biomarker for identifying patients with cardiovascular risk, treating ischemic diseases, and creating tissue-engineered vascular and heart valve constructs.
FAQs
During fetal development, umbilical arteries arise from the internal iliac arteries and extend into the umbilical cord. This developmental connection creates a continuous route between fetal circulation and the placenta, allowing blood carrying metabolic waste to reach the exchange organ. Their origin and pathway therefore link vessel anatomy with the changing requirements of fetal-placental circulation.
The direction of flow reflects their role in the fetal-placental circuit: blood leaves the fetus through the arteries, reaches the placenta, and returns through the umbilical vein after exchange. The placenta replaces carbon dioxide and metabolic waste with oxygen and nutrients, so blood traveling through the arteries is relatively deoxygenated despite their arterial classification.
The umbilical arteries and vein support opposite parts of the same exchange pathway. Arterial flow carries blood and metabolic waste away from the fetus toward the placenta, whereas venous return follows placental exchange and brings oxygenated blood back. This contrast demonstrates that vessel names describe circulation routes, not simply whether the blood contains more or less oxygen.
Vascular resistance provides a functional measure of how blood-flow patterns behave within the umbilical arteries. Doppler assessment can examine these patterns and relate them to the condition of fetal-placental circulation. Because the vessels connect the fetus with the placenta, their flow characteristics contribute to evaluations of fetal well-being and placental performance.
In prenatal assessment, Doppler evaluation of the umbilical arteries provides information about vascular resistance and blood-flow patterns. These measurements support assessment of fetal well-being within the context of placental circulation. The approach connects vessel physiology with clinical observation without examining the arteries as isolated structures, making it relevant to fetal and placental health.
Research on these vessels can investigate how fetal development establishes placental circulation, how the placenta supports exchange, and how blood-flow patterns relate to prenatal health. Their anatomy offers structural context, while Doppler-derived vascular information adds a functional perspective. Together, these features make the vessels useful for studying interactions between fetal circulation and placental function.