Uterine Spiral Arterioles
Uterine Spiral Arterioles - Related Videos
09:49
Isolation and Cannulation of Cerebral Parenchymal Arterioles
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Cited by 28 •
2016
This manuscript describes a simple and reproducible protocol for isolation of intracerebral arterioles (a group of blood vessels encompassing parenchymal arterioles, penetrating arterioles and pre-capillary arterioles) from mice, to be used in pressure myography, immunofluorescence, biochemistry, and molecular studies.
03:41
Preparing Cerebral Endothelial Tubes from Mouse Parenchymal Arterioles
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2025
This video demonstrates a method for isolating the endothelial tubes from mouse cerebral parenchyma. Through a combination of enzymatic digestion and mechanical dissociation, the process yields an intact tube with endothelial cells.
07:35
Preparation Steps for Measurement of Reactivity in Mouse Retinal Arterioles Ex Vivo
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Cited by 12 •
2018
Many vision-threatening ocular diseases are associated with dysfunctional retinal microvessels. Therefore, the measurement of retinal arteriole responses is important to investigate the underlying pathophysiological mechanisms. This article describes a detailed protocol for mouse retinal arteriole isolation and preparation to assess the effects of vasoactive substances on vascular diameter.
02:35
Culturing Murine Spiral Ganglion Neuron Explants on Multielectrode Arrays
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2025
This video demonstrates the process for isolating spiral ganglion explants from the inner ear and co-culturing them with the organ of Corti on a multielectrode array. Spiral ganglia are carefully extracted and sectioned into smaller tissue sections or explants. These explants are cultured on the multielectrode array's active area to promote neuronal process outgrowth.
01:16
Arteries and Arterioles
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2024
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles and...
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Hormonal control drives cyclical changes in the arterioles within the endometrium, allowing blood supply to the uterine lining to vary over time. During pregnancy, this regulation is accompanied by structural remodeling rather than only short-term vascular adjustment. Studying these hormone-linked changes helps connect uterine vascular behavior with endometrial function and the later demands of placental development.
Trophoblast invasion alters the vessel walls by reducing their normal muscular and vasoconstrictive properties. The arterioles consequently become wider and offer lower resistance to maternal blood flow. This transformation changes them from vessels capable of stronger constriction into a circulation suited to sustained delivery of maternal blood to the placental intervillous space as pregnancy progresses.
Reduced vasoconstrictive capacity helps maintain wider, low-resistance channels supplying the intervillous space. That vascular state supports the delivery of maternal blood required for placental exchange and contributes to regulation of oxygen and nutrient availability for the fetus. The mechanism is therefore important because successful placentation depends not only on invasion, but also on the resulting functional change in maternal vessels.
When remodeling is impaired, the maternal vessels may not acquire the adaptations needed for effective placental perfusion. The overview links this abnormal placentation with preeclampsia and fetal growth restriction, indicating that inadequate vascular transformation can affect both maternal cardiovascular biology and fetal development. Spiral arteriole behavior therefore provides an important connection between placental formation and pregnancy complications.
They provide a vascular perspective on how the endometrium changes during the reproductive cycle and how pregnancy reshapes maternal blood flow for placental function. Research on these vessels helps examine the relationship among hormonal regulation, trophoblast invasion, vascular resistance, and placental exchange. Their study therefore contributes to broader understanding of reproductive biology and the maternal adaptations required during pregnancy.
Analysis of remodeling can indicate whether placentation is progressing toward the wider, low-resistance circulation needed for effective exchange. Differences from this expected adaptation may help researchers investigate impaired placentation, preeclampsia, or fetal growth restriction. Because the vessels connect maternal circulation with placental demands, they are also relevant to maternal cardiovascular studies focused on vascular adaptation during pregnancy.