Skin Cancer Diagnosis
Skin Cancer Diagnosis - Related Videos
01:30
Skin Cancer
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2023
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise. Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
09:37
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Cited by 9 •
2022
Here, we describe protocols for acquiring good-quality images using novel, noninvasive imaging devices of reflectance confocal microscopy (RCM) and combined RCM and optical coherence tomography (OCT). We also familiarize clinicians with their clinical applications so that they can integrate the techniques into regular clinical workflows to improve patient care.
03:02
Chemical-induced Two-stage Skin Carcinogenesis Model: An Experimental In Vivo Mouse Model of Skin Cancer
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2023
This video describes the procedure to induce two-stage skin carcinogenesis to study tumor initiation by topical application of chemicals. In the first step, a mutagen, DMBA, is applied onto the skin of a mouse model which initiates tumor formation by causing mutations in the stem cells, followed by the application of a growth stimulator, TPA, which accelerates skin papilloma formation.
06:08
Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging
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Cited by 69 •
2011
We demonstrated that malignant pigmented lesions with increased metabolic activity generate quantifiable amounts of heat and the measurement of the transient thermal response of the skin to a cooling excitation allows quantitative identification of melanoma and other skin cancers (vs. non-proliferative nevi) at an early stage of the disease.
07:34
FISH for Pre-implantation Genetic Diagnosis
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Cited by 17 •
2011
This article describes the selection of suitable probes for single-cell FISH, spreading techniques for blastomere nuclei, and in situ hybridization and signal scoring, applied to pre-implantation genetic diagnosis (PGD) in a clinical setting.
FAQs
Dermoscopy complements the initial skin examination by providing a more structured assessment of lesion features. It helps clinicians decide which growths require tissue confirmation when visual findings raise concern. This tool supports clinical judgment before histopathology, but it does not replace microscopic examination when malignancy remains suspected.
Histopathological analysis provides diagnostic confirmation that surface examination cannot supply. Microscopic review of the tissue can identify whether the growth is benign, precancerous, or malignant and can establish the tumor type. It also documents features such as depth, giving clinicians evidence for classification and subsequent treatment decisions.
Molecular testing adds another layer of characterization for selected tumors rather than serving as a universal first step. Used alongside clinical and microscopic assessment, it may provide information about tumor characteristics that supports classification. In cancer research, this information also contributes to the development of targeted therapies for appropriate tumor groups.
Accurate classification requires more than recognizing an abnormal growth. Separating melanoma from nonmelanoma skin cancers establishes a clinically meaningful tumor category, while recording depth and spread adds information about disease status. Together, these findings support prognosis, meaning an estimate of expected disease behavior, and enable more consistent comparison among research cases.
The workflow begins with visual examination and dermoscopy of the lesion. If the findings warrant further evaluation, clinicians remove a tissue sample for microscopic histopathological analysis. Molecular testing may then be added for selected tumors to provide further characterization. This sequence combines initial lesion assessment with tissue-based confirmation and optional molecular information.
In cancer research, diagnostic findings generate standardized information about tumor type, depth, and spread. Investigators can use these data to classify cases, examine prognosis, and evaluate patterns relevant to early detection. The same framework supports development of improved screening approaches and targeted therapies based on characteristics identified in selected tumors.