Surface Functionalization Method
Surface Functionalization Method - Related Videos
10:40
A Method of Targeted Cell Isolation via Glass Surface Functionalization
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Cited by 6 •
2016
This protocol describes customizable surface functionalization of the desthiobiotin, streptavidin, and APTES system in order to isolate specific cell types of interest. In addition, this manuscript covers the applications, optimization, and verification of this process.
09:12
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
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Cited by 15 •
2018
We have engineered the capsid protein of hepatitis E virus as a theranostic nanoparticle (HEVNP). HEVNP self-assembles into a stable icosahedral cage in mucosal delivery. Here, we describe the modification of HEVNPs for tumor targeting by mutating surface-exposed residues to cysteines, which conjugate synthetic ligands that specifically bind tumor cells.
09:20
A Method to Manipulate Surface Tension of a Liquid Metal via Surface Oxidation and Reduction
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Cited by 12 •
2016
We present a method to control the interfacial energy of a liquid metal in an electrolyte via electrochemical deposition (or removal) of a surface oxide layer. This simple method can control the capillary behavior of gallium-based liquid metals by tuning the interfacial energy rapidly, significantly, and reversibly using modest voltages.
08:25
Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
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Cited by 5 •
2016
The present protocol aims at assessing cognitive-emotional functions in the basal ganglia by simultaneous neurophysiological recording of local field potentials and non-invasive brain cortical activity (EEG). The procedure is exemplified by the use of paradigms involving speech stimuli with emotional connotation or the Flanker task involving cognitive control.
10:03
Swab Sampling Method for the Detection of Human Norovirus on Surfaces
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Cited by 40 •
2017
A macrofoam based sampling methodology was developed and evaluated for the detection and quantification of norovirus on environmental hard surfaces.
FAQs
Surface functionalization can use covalent bonding, adsorption, or self-assembled monolayers, and these routes differ in how the added species are held at the interface. Covalent attachment forms chemical bonds, whereas adsorption relies on interaction with the surface; self-assembled monolayers provide another route for organizing surface-bound material. Choosing among them changes the resulting interface and its interaction with the surroundings.
The central design advantage is that the outermost layer can be altered while the bulk material remains unchanged. This separates interfacial functions from bulk properties: an attached chemical group or coating can change wettability, charge, reactivity, or biocompatibility without requiring wholesale modification of the material. That distinction helps chemists tailor surface behavior while retaining the underlying material’s established role.
The identity of an introduced chemical group, molecule, or coating determines which interactions the surface presents to its surroundings. Changing that chemistry can tune wettability, charge, reactivity, or biocompatibility, giving the interface a different functional character. These changes provide the chemical basis for designing surfaces suited to adhesion, sensing, catalysis, corrosion resistance, or biological compatibility.
A practical design begins by identifying the desired interfacial property, then selecting a compatible chemical group, molecule, or coating and an attachment route. Covalent bonding, adsorption, self-assembled monolayers, and other surface reactions offer different ways to place the modification at the outer layer. The selected combination should support the intended change in wettability, charge, reactivity, or biocompatibility.
Surface functionalization addresses interface-specific performance problems, including poor adhesion, corrosion, limited catalytic activity, weak sensor performance, and inadequate biocompatibility. By changing the chemistry presented at the outer layer, the method targets how a material interacts with its surroundings rather than necessarily replacing the underlying material. This makes it useful when interfacial improvement is more appropriate than bulk modification.
The approach applies across nanomaterials, polymers, metals, catalysts, and biomedical devices, where surface interactions strongly influence performance. In chemistry research, it supports tailored interfaces for catalytic activity, sensor behavior, corrosion resistance, adhesion, and biological compatibility. Its broad material scope reflects the fact that the same outer-layer design principle can be adapted to very different underlying substrates.