Mechanical Validation

Mechanical validation is the systematic evaluation of how a medical device, implant, prosthesis, or biomaterial responds to physical forces under defined conditions. It works by applying controlled loads, pressures, motion, or repeated cycles while measuring properties such as stress, strain, deformation, strength, stiffness, and fatigue resistance against predetermined performance criteria. In medicine, these tests help determine whether products can withstand expected use, maintain structural integrity, and function safely in the body. Mechanical validation supports device development, quality assurance, regulatory submissions, and risk assessment, while also informing improvements to materials, design, manufacturing processes, and patient-specific applications.

Mechanical Validation - Related Videos

Education

JoVE Core - Social Psychology

Reliability and Validity

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2020

Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways. Unfortunately, being consistent in measurement does not necessarily mean that you have measured something correctly. To illustrate this concept, consider a kitchen...

Research

JoVE Journal - Medicine

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

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Cited by 12 •

2023

The present protocol describes an integrated strategy for exploring the key targets and mechanisms of Fructus Phyllanthi against hyperlipidemia based on network pharmacology prediction and metabolomics verification.

Mechanical Stimulation of Chondrocyte-agarose Hydrogels

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Cited by 29 •

2012

The biosynthesis of cartilaginous extracellular matrix by chondrocytes can be affected by application of mechanical stimuli. This method describes the technique of applying dynamic compressive strains to chondrocytes encapsulated in 3D constructs and the evaluation of induced changes in chondrocyte metabolism.

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

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Cited by 3 •

2023

This study reveals the mechanism of Trichosanthes-Fritillaria thunbergii in treating lung adenocarcinoma based on network pharmacology and experimental verification. The study also demonstrates that the PI3K/AKT signaling pathway plays a vital role in the action of Trichosanthes-Fritillaria thunbergii in treating lung adenocarcinoma.

Data Validation

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2023

Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible. Nursing assessment guides are generally based on holistic models rather than medical...

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