Total Kidney Volume
Total Kidney Volume - Related Videos
08:19
The Mouse Isolated Perfused Kidney Technique
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Cited by 24 •
2016
The mouse isolated perfused kidney (MIPK) is a technique for keeping a mouse kidney under ex vivo conditions perfused and functional for 1 hr. The buffers and surgical technique are described in detail.
10:42
Normothermic Machine Perfusion of Rat Kidneys for Transplantation
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2026
This protocol describes the ex vivo normothermic machine perfusion of a rat kidney for subsequent transplantation into a recipient rat.
01:45
Kidney Structure
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2019
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries. The renal cortex is the thick outer layer of the kidney. It...
03:14
Vibratome Sectioning of Whole Murine Kidney: A Technique to Generate Thin Sections of Murine Kidney
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2023
In this video, we demonstrate the vibratome sectioning of a whole mouse kidney to obtain thin slices. These sliced tissue sections can be stored at low temperatures until further downstream analysis.
06:56
Isolation of Double Negative αβ T Cells from the Kidney
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Cited by 26 •
2014
DNabT cells are rare among peripheral T cells; however, they are abundant in certain non-lymphoid tissues. Difficulty of isolating DN T cells from non-lymphoid tissue hinders their functional analysis despite increasing recognized pathophysiologic significance. We describe a novel protocol for isolation of highly purified DN T cells from murine kidney.
FAQs
In autosomal dominant polycystic kidney disease, cyst growth can enlarge the kidneys, so increasing total kidney volume provides an imaging-based sign of structural disease change. This makes the measurement useful for evaluating how the condition is progressing rather than relying only on a single clinical snapshot. It can therefore support prognosis and patient risk stratification in affected patients.
A single measurement describes renal size at one point, whereas serial total kidney volume measurements allow clinicians to compare structural status over time. That longitudinal comparison can reveal whether kidney enlargement is changing and can help assess disease progression. It also provides a basis for evaluating therapeutic effects when measurements are obtained at multiple time points.
Reliable results depend on accurately identifying the boundaries of both kidneys in the images. Each outlined region must represent the kidney tissue enclosed by its boundary before the two volumes are combined. Consistent delineation matters because the resulting value is used for comparisons over time, prognosis, risk stratification, and treatment-related assessment.
Yes. The measurement can be derived from either computed tomography or magnetic resonance images by outlining the boundaries of each kidney and calculating the enclosed volume. The choice described in the source is therefore an imaging-based workflow rather than a measurement based on external dimensions. Either approach supports quantification of renal size.
The workflow begins with CT or MRI images that display both kidneys. The boundaries of each kidney are outlined, and the enclosed volume is calculated separately for each one. Those two measurements are then summed to obtain the combined value. Repeating the same type of assessment over time enables longitudinal comparison of structural change.
Clinicians can use the measurement to support prognosis, classify patient risk, inform treatment decisions, and evaluate therapeutic effects. Its value comes from linking a quantified structural feature with change over time, particularly in autosomal dominant polycystic kidney disease, where cyst growth may enlarge the kidneys. Thus, it can contribute to both baseline assessment and follow-up of disease management.