Brain Gut Peptides
Brain Gut Peptides - Related Videos
17:36
Testing Protozoacidal Activity of Ligand-lytic Peptides Against Termite Gut Protozoa in vitro (Protozoa Culture) and in vivo (Microinjection into Termite Hindgut)
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Cited by 14 •
2010
We present procedures for demonstrating that ligands bind to the surface membrane of the cellulose-digesting protozoa in the gut of Formosan subterranean termites using fluorescent microscopy and that ligands coupled with lytic peptides kill these protozoa in vitro (anaerobic protozoa culture) and in vivo (injection into the termite hindgut).
01:22
Gut-Brain Axis
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2026
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
04:59
Visualization of Amyloid-Beta Peptides in Human Cortical Brain Slices
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2025
The video demonstrates a procedure for preparing human cortical brain slices from Alzheimer's disease patients for analyzing the deposition of amyloid-beta (Aβ) peptides using Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS). The steps include preparing the slides, treating the tissue to enhance ionization, and analyzing the spatial distribution of amyloid-beta peptides.
02:47
Establishing an Alzheimer's Disease Model in Zebrafish Brain Through Amyloid Peptide Injection
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2025
This video demonstrates the procedure of injecting monomeric amyloid peptides into the forebrain of adult zebrafish to generate amyloid toxicity, mimicking the neuronal damage seen in Alzheimer's...
15:27
Extracting DNA from the Gut Microbes of the Termite (Zootermopsis Angusticollis) and Visualizing Gut Microbes
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Cited by 17 •
2007
This video illustrates the technique for extracting DNA from the species of microbes resident in the termite hindgut. The preparation of a wet mount slide, which is useful for visualizing the gut microbial community is also illustrated, and a tour through the species-rich gut environment is given.
FAQs
These peptides can influence physiology through circulating signals and through the vagus nerve, which connects the gastrointestinal tract with the nervous system. After binding receptors on gut, vagal, or central neurons, they can alter neuronal activity and hormone release. Considering both routes helps explain how digestive conditions reach the brain and how brain responses can affect bodily regulation.
Receptors on vagal neurons provide a pathway for gastrointestinal signals to reach the nervous system, while receptors on central neurons allow peptides to act more directly within the brain. This arrangement links internal bodily states with neural processing. Studying these receptor locations helps researchers connect digestion and energy regulation with motivation, stress, learning, and behavior.
Ghrelin, cholecystokinin, and glucagon-like peptide-1 are useful examples for examining how gut-derived signals influence neural and hormonal responses. Their receptor-mediated actions can be studied in relation to appetite, digestion, and energy balance, as well as broader brain functions. Comparing these peptides helps clarify how distinct gastrointestinal signals participate in coordinated body-brain regulation.
These pathways provide a framework for studying how conditions inside the body influence motivation, stress, learning, and behavior. Changes in digestion, appetite, or energy balance can be considered alongside neuronal activity and hormone release. This neuroscience perspective treats bodily signals as contributors to brain function rather than viewing behavior as independent of gastrointestinal and metabolic conditions.
Brain-gut peptide signaling is relevant to obesity and diabetes because the same pathways participate in appetite and energy balance, while also regulating hormone release. Research can therefore examine how peptide-receptor interactions connect gastrointestinal information with central neural activity and metabolic control. These connections support investigation of disease mechanisms and the development of potential peptide-based therapies.
Disrupted communication between gastrointestinal tissues, the vagus nerve, circulating signals, and the brain could help explain how gastrointestinal conditions relate to neural and hormonal changes. Studying these connections may identify signaling processes relevant to gastrointestinal disorders and reveal therapeutic opportunities. In particular, peptide-based approaches are being considered because these molecules can influence both bodily regulation and brain-related pathways.