Nerve Cells
Nerve Cells - Related Videos
05:40
In Vivo Gene Transfer to Schwann Cells in the Rodent Sciatic Nerve by Electroporation
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Cited by 4 •
2016
Here, we present an in vivo technique for gene transfer to Schwann cells (SCs) in the rodent sciatic nerve. This simple technique is useful for investigating signaling mechanisms involved in the development and maintenance of myelinating SCs.
02:30
Gene Transfer into Schwann Cells of the Rodent Sciatic Nerve via Electroporation
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2025
Source: Ino, D. et. al., In Vivo Gene Transfer to Schwann Cells in the Rodent Sciatic Nerve by Electroporation. J. Vis. Exp. (2016)This video demonstrates in vivo gene transfer to Schwann cells of the rodent sciatic nerve using electroporation. A plasmid DNA–dye solution is injected into the nerve, and electric pulses facilitate DNA entry. The DNA later integrates into the cell’s genome, enabling successful gene transfer in Schwann cells.
03:19
Magnetic Separation of Schwann Cells from Mouse Sciatic Nerves
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2025
This video demonstrates a method for isolating Schwann cells from mouse sciatic nerve fibers.
08:16
Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro
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Cited by 7 •
2020
Here, we present a method to purify fibroblasts and Schwann cells from sensory and motor nerves in vitro.
03:51
Murine Sciatic Nerve Model of Perineural Invasion or PNI: Extraction and Processing of Sciatic Nerve to Understand Invasion by Cancer Cells
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2025
In this video, we describe the procedure to establish a murine model of perineural invasion by injecting cancer cells into the sciatic nerve. The model can help gain an understanding of the magnitude of nerve invasion for subsequent assessment of anti-cancer drugs.
FAQs
An action potential carries information electrically along a nerve cell, while neurotransmitter release transfers that information across a synapse. The receiving cell may then be excited or inhibited, influencing whether signaling continues through the network. This combination allows neural communication to move between cells while also changing the activity of connected circuits.
Excitatory signals increase the likelihood that neighboring nerve cells will become active, whereas inhibitory signals reduce that likelihood. Their interaction helps determine how strongly a neural circuit responds to incoming information. In psychology, this balance is relevant because circuit activity supports processes such as perception, emotion, motivation, and decision-making.
Synapses determine how signals pass between connected nerve cells, so changes in synaptic function can alter communication within neural circuits. Those altered patterns of signaling may affect how information is processed and retained. Studying these changes gives psychology a cellular basis for investigating learning and memory rather than treating them only as observable behaviors.
An individual nerve cell reveals how electrical signals and neurotransmitters handle information locally. A neural circuit examines how many connected cells coordinate their activity to support a broader function. This distinction matters because psychological abilities, including thought, emotion, and behavior, depend on organized communication across networks rather than on isolated cellular events alone.
Psychological research uses knowledge of neuronal communication to connect cellular activity with sensation, thought, emotion, and behavior. Researchers can ask how signaling within neural circuits may support learning, memory, motivation, perception, or decision-making. This framework helps interpret behavioral findings in relation to the underlying information processing performed by the nervous system.
Changes in synaptic function can disrupt communication within neural circuits, helping explain how biological alterations may relate to depression, anxiety, epilepsy, and neurodegenerative disease. Examining these changes connects symptoms and behavior with cellular processes. It also supports the development of more targeted interventions aimed at specific aspects of neuronal communication rather than broad effects alone.