Ian Parker

Department of Neurobiology and Behaviour, University of California, Irvine (UCI)

Affiliated withUniversity of California, Irvine (UCI)University of California, Irvine

Research Area

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title Cited by 20	2007
Publication title Cited by 71	2008
Publication title Cited by 2	2008
Publication title Cited by 17	2015
Publication title Cited by 5	2015

Other Publications

Article	Year
A Preliminary Study of the Spreading of AKD in the Presence of Capillary Structures. Journal of colloid and interface science\| PubMed ID: 11446799	2001
Structural and functional relationships between Ca2+ puffs and mitochondria in Xenopus oocytes. American journal of physiology. Cell physiology\| PubMed ID: 11997252	2002
Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science (New York, N.Y.)\| PubMed ID: 12016203	2002
Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells. The Journal of biological chemistry\| PubMed ID: 12087110	2002
Two-photon imaging in intact lymphoid tissue. Advances in experimental medicine and biology\| PubMed ID: 12405205	2002
Two-photon tissue imaging: seeing the immune system in a fresh light. Nature reviews. Immunology\| PubMed ID: 12415310	2002
Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms. The Journal of biological chemistry\| PubMed ID: 12454006	2003
Ca2+ signaling in mouse cortical neurons studied by two-photon imaging and photoreleased inositol triphosphate. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12574404	2003
Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12601158	2003
Photonics for biologists. Methods in enzymology\| PubMed ID: 12622159	2003
Video-rate confocal microscopy. Methods in enzymology\| PubMed ID: 12622163	2003
Real-time imaging of lymphocytes in vivo. Current opinion in immunology\| PubMed ID: 12900266	2003
A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunological reviews\| PubMed ID: 12969316	2003
Buffer kinetics shape the spatiotemporal patterns of IP3-evoked Ca2+ signals. The Journal of physiology\| PubMed ID: 14555715	2003
Optical single-channel recording: imaging Ca2+ flux through individual N-type voltage-gated channels expressed in Xenopus oocytes. Cell calcium\| PubMed ID: 14572808	2003
T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14722354	2004
Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14724250	2004
Spatiotemporal patterning of IP3-mediated Ca2+ signals in Xenopus oocytes by Ca2+-binding proteins. The Journal of physiology\| PubMed ID: 14755000	2004
Early experiences with computed axial tomography colonography. American journal of surgery\| PubMed ID: 15041501	2004
Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15090649	2004
Imaging the activity and localization of single voltage-gated Ca(2+) channels by total internal reflection fluorescence microscopy. Biophysical journal\| PubMed ID: 15111438	2004
Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. The Journal of experimental medicine\| PubMed ID: 15466619	2004
Two phases of zymogen granule lifetime in mouse pancreas: ghost granules linger after exocytosis of contents. The Journal of physiology\| PubMed ID: 15637100	2005
Dynamic multiphoton imaging: a live view from cells to systems. Physiology (Bethesda, Md.)\| PubMed ID: 15653835	2005
A model-independent algorithm to derive Ca2+ fluxes underlying local cytosolic Ca2+ transients. Biophysical journal\| PubMed ID: 15681645	2005
Imaging single-channel calcium microdomains by total internal reflection microscopy. Biological research\| PubMed ID: 15709697	2004
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. The Journal of biological chemistry\| PubMed ID: 15722360	2005
Optical single-channel recording by imaging Ca2+ flux through individual ion channels: theoretical considerations and limits to resolution. Cell calcium\| PubMed ID: 15755490	2005
Optical single-channel recording: imaging Ca2+ flux through individual ion channels with high temporal and spatial resolution. Journal of biomedical optics\| PubMed ID: 15847568	2005
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS biology\| PubMed ID: 15857154	2005
In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. The Journal of experimental medicine\| PubMed ID: 15928201	2005
"Optical patch-clamping": single-channel recording by imaging Ca2+ flux through individual muscle acetylcholine receptor channels. The Journal of general physiology\| PubMed ID: 16103278	2005
Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node. Seminars in immunology\| PubMed ID: 16263308	2005
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nature immunology\| PubMed ID: 16273098	2005
Analysis of puff dynamics in oocytes: interdependence of puff amplitude and interpuff interval. Biophysical journal\| PubMed ID: 16533853	2006
Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16687509	2006
Plasmalemmal Ca2+ signaling in arterial smooth muscle: it's elementary! The Journal of general physiology\| PubMed ID: 16702356	2006
Imaging Ca2+ signals in Xenopus oocytes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 16739719	2006
Imaging the choreography of lymphocyte trafficking and the immune response. Current opinion in immunology\| PubMed ID: 16765574	2006
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nature chemical biology\| PubMed ID: 16829954	2006
'Trigger' events precede calcium puffs in Xenopus oocytes. Biophysical journal\| PubMed ID: 16980363	2006
The number and spatial distribution of IP3 receptors underlying calcium puffs in Xenopus oocytes. Biophysical journal\| PubMed ID: 16980372	2006
Imaging single-channel calcium microdomains. Cell calcium\| PubMed ID: 17067668	2006
Psychoanalytic cyberspace, beyond psychology. Psychoanalytic review\| PubMed ID: 17367277	2007
Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Human molecular genetics\| PubMed ID: 17400654	2007
Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models. Annals of the New York Academy of Sciences\| PubMed ID: 17413028	2007
A kinetic model of single and clustered IP3 receptors in the absence of Ca2+ feedback. Biophysical journal\| PubMed ID: 17526578	2007
Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17609379	2007
Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17641025	2007
Swingers: bonobos are celebrated as peace-loving, matriarchal, and sexually liberated. Are they? New Yorker (New York, N.Y. : 1925)\| PubMed ID: 17650578	2007
Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17675487	2007
Multi-dimensional resolution of elementary Ca2+ signals by simultaneous multi-focal imaging. Cell calcium\| PubMed ID: 17716727	2008
Mode switching is the major mechanism of ligand regulation of InsP3 receptor calcium release channels. The Journal of general physiology\| PubMed ID: 17998395	2007
Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annual review of immunology\| PubMed ID: 18173372	2008
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. The Journal of cell biology\| PubMed ID: 18591429	2008
Localization of puff sites adjacent to the plasma membrane: functional and spatial characterization of Ca2+ signaling in SH-SY5Y cells utilizing membrane-permeant caged IP3. Cell calcium\| PubMed ID: 18639334	2009
Modeling Ca2+ feedback on a single inositol 1,4,5-trisphosphate receptor and its modulation by Ca2+ buffers. Biophysical journal\| PubMed ID: 18641077	2008
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. The Journal of general physiology\| PubMed ID: 18663130	2008
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature\| PubMed ID: 18820677	2008
Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo. PloS one\| PubMed ID: 18820727	2008
Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity\| PubMed ID: 18835197	2008
cADPR stimulates SERCA activity in Xenopus oocytes. Cell calcium\| PubMed ID: 19131109	2009
Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19332787	2009
Chapter 16. Two-photon microscopy and multidimensional analysis of cell dynamics. Methods in enzymology\| PubMed ID: 19480927	2009
Acquisition of chemiluminescent signals from immunoblots with a digital single-lens reflex camera. Analytical biochemistry\| PubMed ID: 19788886	2010
Ca(2+) puffs originate from preestablished stable clusters of inositol trisphosphate receptors. Science signaling\| PubMed ID: 19934435	2009
NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20139277	2010
Calcium signaling and amyloid toxicity in Alzheimer disease. The Journal of biological chemistry\| PubMed ID: 20212036	2010
Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20404167	2010
Modulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+ signals. The Journal of biological chemistry\| PubMed ID: 20538594	2010
A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20592201	2010
Superresolution localization of single functional IP3R channels utilizing Ca2+ flux as a readout. Biophysical journal\| PubMed ID: 20643061	2010
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell\| PubMed ID: 20655468	2010
Recording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp. The Journal of general physiology\| PubMed ID: 20660654	2010
General approach to adoptive transfer and cell labeling for immunoimaging. Cold Spring Harbor protocols\| PubMed ID: 21285265	2011
Induction of an immune response for imaging antigen-presenting cell/T-cell interactions. Cold Spring Harbor protocols\| PubMed ID: 21285266	2011
In situ lymph node imaging. Cold Spring Harbor protocols\| PubMed ID: 21285267	2011
In vivo lymph node imaging. Cold Spring Harbor protocols\| PubMed ID: 21285268	2011
Immunoimaging: studying immune system dynamics using two-photon microscopy. Cold Spring Harbor protocols\| PubMed ID: 21285279	2011
Active generation and propagation of Ca2+ signals within tunneling membrane nanotubes. Biophysical journal\| PubMed ID: 21504718	2011
Enhanced ER Ca2+ store filling by overexpression of SERCA2b promotes IP3-evoked puffs. Cell calcium\| PubMed ID: 21616533	2011
Discursive social psychology now. The British journal of social psychology / the British Psychological Society\| PubMed ID: 21790666	2011
Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21987805	2011
Single-channel Ca(2+) imaging implicates AÎ²1-42 amyloid pores in Alzheimer's disease pathology. The Journal of cell biology\| PubMed ID: 22024165	2011
Timescales of IP(3)-Evoked Ca(2+) Spikes Emerge from Ca(2+) Puffs Only at the Cellular Level. Biophysical journal\| PubMed ID: 22261051	2011
Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22511718	2012
Multi-scale data-driven modeling and observation of calcium puffs. Cell calcium\| PubMed ID: 22682010	2012
The probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster. Biophysical journal\| PubMed ID: 22768938	2012
Cytosolic [Ca2+] regulation of InsP3-evoked puffs. The Biochemical journal\| PubMed ID: 23035871	2013
Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins. The Journal of biological chemistry\| PubMed ID: 23300080	2013
Temperature dependence of IP3-mediated local and global Ca2+ signals. Biophysical journal\| PubMed ID: 23442860	2013
Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23447594	2013
Orai1 function is essential for T cell homing to lymph nodes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23455504	2013
Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. PloS one\| PubMed ID: 23533579	2013
Factors determining the recruitment of inositol trisphosphate receptor channels during calcium puffs. Biophysical journal\| PubMed ID: 24314078	2013
Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24843159	2014
Termination of calcium puffs and coupled closings of inositol trisphosphate receptor channels. Cell calcium\| PubMed ID: 25016315	2014
An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imaging. Cell calcium\| PubMed ID: 25047761	2014
Single-molecule tracking of inositol trisphosphate receptors reveals different motilities and distributions. Biophysical journal\| PubMed ID: 25140418	2014
Fluorescence microscopy. Cold Spring Harbor protocols\| PubMed ID: 25275114	2014
Modulation of elementary calcium release mediates a transition from puffs to waves in an IP3R cluster model. PLoS computational biology\| PubMed ID: 25569772	2015
Molecular Biophysics of Orai Store-Operated Ca(2+) Channels. Biophysical journal\| PubMed ID: 25606672	2015
Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming. Nature communications\| PubMed ID: 25653051	2015