Skin Drug Delivery
Skin Drug Delivery - Related Videos
06:37
Skin Tattooing As A Novel Approach For DNA Vaccine Delivery
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Cited by 6 •
2012
Skin tattooing is a potent and safe way to delivery DNA vaccine intradermally. Here, a DNA plasmid encoding EGFP is delivered by tattooing to the skin of a laboratory mouse, and the expression of EGFP in the skin cells is then inspected by confocal microscopy.
03:37
Intranasal Drug Administration in Mice via Pipette and Reverse-Cannulation for Nose-to-Brain Drug Delivery
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2025
Source: Kanazawa, T., et al. Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery. J. Vis. Exp. (2018)This video demonstrates the intranasal administration of radiolabeled drugs in an anesthetized mouse to achieve nose-to-brain drug delivery. It explains how drugs cross the nasal epithelium and travel via neuronal pathways to reach the brain, as well as how ciliary motion influences drug retention and clearance. Additionally, the video...
02:37
Ophthalmic Drug Delivery for Noninvasive Neuromodulation in a Mouse Model
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2025
Source: Zhan, J., et al. Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity. J. Vis. Exp. (2019)This video demonstrates a non-invasive ophthalmic drug delivery method for targeted neuromodulation. The drug is delivered via eye drops, absorbed into the circulation, crosses the blood-brain barrier, and activates specific neuronal receptors.
04:36
Canalostomy for Local Drug Delivery into the Inner Ear of an Adult Mouse
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2025
This video showcases canalostomy, a procedure that allows local drug delivery into the inner ear of a mouse through the semicircular canal with minimal damage to hearing and vestibular function. This method enables the inoculation of viral vectors, pharmaceuticals, and small molecules into the mouse's inner ear.
14:55
Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
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Cited by 172 •
2013
We describe a method to target drugs to the central nervous system by either implanting a catheter or performing a bolus injection into the right lateral ventricle in mice. We focus specifically on the delivery of antisense oligonucleotides. This technique is readily adaptable to other drugs and to rats.
FAQs
The stratum corneum is the main rate-limiting barrier to skin penetration, so drug movement depends strongly on diffusion across this layer. Molecular size and lipophilicity affect how readily a compound passes through it, while formulation properties can alter release and transport. These variables help determine whether treatment remains near the application site or reaches systemic circulation.
Chemical enhancers and microneedles address the skin barrier through different design strategies. Enhancers modify permeability so a compound can move more readily through the skin, whereas microneedles provide a minimally invasive delivery approach. Bioengineers select between these options according to the desired transport behavior, tissue targeting, and need to control exposure.
These factors influence both the ability of a drug to cross the skin and the rate at which it becomes available. Smaller molecules and suitable lipophilicity can support diffusion, while the surrounding formulation controls how the compound is released from a cream, gel, patch, or other system. Together, they shape local concentration and systemic exposure.
Design choices can include creams, gels, patches, nanoparticles, and minimally invasive devices. Each format provides a different way to place the compound at the skin surface, regulate release, or improve tissue targeting. During bioengineering development, the selected system is matched to whether the intended outcome is localized treatment, sustained exposure, or transport into circulation.
Local delivery is appropriate when the therapeutic goal is to act near the application site, including treatments for dermatological disorders, pain, or inflammation. Systemic delivery is considered when drug transport into circulation is needed. Distinguishing these goals guides formulation and device design, because the desired distribution determines how permeability, release, and targeting should be controlled.
Skin-based systems can support sustained drug exposure and may reduce dosing frequency. They can also avoid gastrointestinal degradation, which is relevant when compounds are vulnerable to conditions in the gastrointestinal tract. These advantages make engineered patches, gels, nanoparticles, and related devices useful platforms for developing treatments that require controlled or prolonged delivery.