Blood Sampling
Blood Sampling - Related Videos
07:11
Sampling Blood from the Lateral Tail Vein of the Rat
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Cited by 82 •
2015
Blood samples are useful for assessing biomarkers of physiological states or disease in vivo. Here we describe the methodology to sample blood from the lateral tail vein in the rat. This method provides rapid samples with minimal pain and invasiveness.
04:10
Detection of Rhesus Factor in Human Blood Samples using Magnetic Levitation
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2025
This video demonstrates the detection of the Rhesus (Rh) factor in blood samples using a magnetic levitation instrument. The magnetic field aligns and levitates beads and blood cells based on density. Treating the samples with anti-Rh antibodies results in intermediate-density bead-cell complexes' formation, allowing for the differentiation of Rh-positive and Rh-negative red blood cells.
06:39
Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
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Cited by 1 •
2025
Here, we present a through-the-wall, minimally invasive method to sample blood during sleep in clinical settings.
07:32
Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples
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Cited by 36 •
2012
Circulating tumor cells are isolated from the blood of cancer patients without inflicting cellular damage. Isolation of tumor cells is accomplished using a bimolecular surface of E-selectin in addition to antibodies against epithelial markers. A nanotube coating specifically promotes cancer cell adhesion resulting in high capture purities.
07:58
Non-Terminal Blood Sampling Techniques in Guinea Pigs
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Cited by 25 •
2014
Though a known model, the guinea pig currently represents a niche in experimental animal sciences and limited data is available on the execution of most procedures. Here we present four different approaches to non-terminal in vivo blood sampling techniques in either conscious or anaesthetized guinea pigs.
FAQs
The collection tube helps determine whether the laboratory receives whole blood, plasma, or serum. Tubes with anticoagulants support collection of blood without clotting, whereas tubes without them support a different processed fraction. This choice matters because studies may target cellular components, proteins, hormones, metabolites, pathogens, or immune responses, and the measurable material depends on how the sample is prepared.
Blood samples can support analysis of cells alongside proteins, hormones, metabolites, pathogens, and immune responses. Examining these categories allows researchers to connect measurable blood components with physiological changes, disease processes, treatment effects, or experimental outcomes. The useful target therefore depends on the biological question, rather than on blood sampling alone.
Labeling, storage, and processing help preserve the components that laboratories intend to measure. Accurate labeling maintains the identity of each specimen, while suitable storage and timely processing help protect the sample’s measurable characteristics. These steps are especially important when comparing physiological states, disease-related changes, treatment effects, or results from different experimental conditions.
Venipuncture and capillary puncture are the two collection approaches identified for obtaining blood from a living organism. The appropriate choice depends on the study’s sampling requirements, including the need to minimize sample volume and maintain participant or animal welfare. Whichever approach is selected, subsequent tube handling, labeling, storage, and processing remain essential to reliable analysis.
A basic workflow begins by obtaining the specimen through venipuncture or capillary puncture, placing it in a tube selected for the intended blood fraction, and labeling it correctly. The sample is then stored and processed so its measurable components remain preserved before laboratory analysis. This sequence supports consistent interpretation of biological or experimental outcomes.
Blood sampling is useful when researchers need to assess physiological changes, disease processes, treatment effects, or experimental outcomes. Repeated or comparative measurements can focus on cells, proteins, hormones, metabolites, pathogens, or immune responses, depending on the investigation. Minimizing sample volume and maintaining participant or animal welfare are important considerations when monitoring living organisms.
In biology research, blood provides access to multiple measurable indicators associated with health and biological function. Analyses may examine cellular, molecular, metabolic, infectious, or immune-related findings to evaluate disease processes or treatment effects. Comparing these findings with physiological changes or experimental outcomes helps researchers assess how an organism responds under the conditions being studied.