Nude Mouse Model
Nude Mouse Model - Related Videos
07:12
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Cited by 1 •
2017
The goal of this protocol is to generate a nude rat osteoporosis-related vertebral compression fracture model that can be longitudinally evaluated in vivo using a semiautomated microcomputed tomography-based quantitative structural analysis.
12:23
Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
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Cited by 16 •
2012
In the pathogenesis of bone metastasis, angiogenesis is a crucial process and therefore represents a target for imaging and therapy. Here, we present a rat model of site-specific breast cancer bone metastasis and describe strategies to non-invasively image angiogenesis in vivo using magnetic resonance imaging, volumetric computed tomography and ultrasound.
02:36
Establishing a Mouse Model of Pleural Disseminated Lung Cancer
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2025
This video demonstrates a method to generate a mouse model of pleural dissemination by injecting lung cancer cell suspension into the thoracic cavity of an immunodeficient mouse.
10:32
Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
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Cited by 28 •
2014
Mycobacterium leprae, the causative agent of leprosy, does not grow in vitro. We describe an easy to follow protocol to prepare a bacillary suspension to ensure the maintenance of large quantities of M. leprae for a variety of applications. Protocols for propagation by mouse footpad inoculation, evaluation of viability, freezing and thawing bacillary stock are described in detail.
03:10
Treatment of Brain Tumors in a Mouse Model Using Sonodynamic Therapy
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2025
Source: Mess, G., et al. Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System. J. Vis. Exp. (2023)This video demonstrates a protocol for performing sonodynamic therapy on a brain tumor in a mouse model using magnetic resonance-guided focused ultrasound (MRgFUS). A sonosensitizer precursor is administered prior to treatment, which accumulates in tumor cells and is activated by focused ultrasound to produce reactive...
FAQs
The thymus defect changes adaptive immunity primarily by impairing T-cell development. This reduced rejection creates a permissive setting for implanted human or mouse tumor cells to establish and grow. Importantly, nude mice retain other immune and physiological systems, so tumor behavior is examined in a living organism rather than in a host with completely absent immune function.
Compared with studies in mice with intact immune systems, nude mouse model experiments place less emphasis on T-cell-mediated rejection and more on tumor growth, invasion, metastasis, or treatment response under reduced adaptive immune pressure. This distinction matters when interpreting results because a therapy that performs well in this setting may not produce the same outcome when patient immune function contributes to tumor control.
Nude mouse models can receive either human or mouse tumor cells, depending on the experimental design. That flexibility supports controlled investigation of tumor behavior across different implanted-tumor settings while preserving the same general host context. In cancer research, it enables researchers to evaluate growth, invasion, metastasis, or treatment responses using tumor material relevant to the specific research question.
A basic study involves implanting human or mouse tumor cells into the nude mice and then examining the resulting tumor behavior under controlled biological conditions. Researchers may focus on growth, invasion, or metastasis, or administer an anticancer drug or radiation to evaluate response. The workflow therefore connects tumor establishment with a defined disease or treatment question.
Measurements of tumor growth can be considered alongside invasion and metastasis to characterize how a cancer develops in vivo. These outcomes provide complementary information rather than a single measure of tumor burden: growth reflects expansion, while invasion and metastasis address broader behavior. Together, they help researchers assess disease progression and compare responses to experimental interventions.
They are especially useful for reproducible preclinical evaluation of anticancer drugs and radiation, as well as controlled studies of tumor progression. Their principal limitation is interpretive: reduced adaptive immune function does not reproduce the immune environment of patients with intact immune systems. Consequently, results can guide research decisions but may not fully predict clinical outcomes.